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Tcf proteins are deeply rooted in skin

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Adult mammalian tissues are maintained by multipotent stem cells, many of which are highly responsive to soluble Wnt proteins. A new study reports the requirement of two Tcf family members, Tcf3 and Tcf4, in the development and maintenance of epithelial stem cells in skin through Wnt-dependent and -independent processes.

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Figure 1: Skin includes layers of differentiated lineages of the epidermis, hair follicle and sebaceous gland maintained by epithelial stem cells.

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Authors and Affiliations

  1. David M. Owens is at the Departments of Dermatology and Pathology, Columbia University, College of Physicians & Surgeons, New York, New York, USA.,

    David M Owens

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  1. David M Owens
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Correspondence to David M Owens.

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Owens, D. Tcf proteins are deeply rooted in skin. Nat Genet 41, 1050–1051 (2009). https://doi.org/10.1038/ng1009-1050

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