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The hippocratic finger points the blame at PGE2

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Digital clubbing has been recognized since the time of the ancient Greeks as a sign of systemic disease. Now, a new study identifies a role for prostaglandin E2 in the pathogenesis of digital clubbing observed in familial hypertrophic osteoarthropathy.

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Figure 1

Sarah R. Keilson

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Authors and Affiliations

  1. Kenneth G. Coggins is in the Department of Medicine, Carolinas Medical Center, Charlotte, North Carolina 28203, USA.,

    Kenneth G Coggins

  2. Thomas M. Coffman is in the Division of Nephrology, Department of Medicine, Duke University, North Carolina 27710, USA.,

    Thomas M Coffman

  3. Beverly H. Koller is in the Departments of Genetics and Medicine, Division of Pulmonary and Critical Care, University of North Carolina at Chapel Hill, North Carolina 27599, USA. treawouns@aol.com,

    Beverly H Koller

Authors
  1. Kenneth G Coggins
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  2. Thomas M Coffman
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  3. Beverly H Koller
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Coggins, K., Coffman, T. & Koller, B. The hippocratic finger points the blame at PGE2. Nat Genet 40, 691–692 (2008). https://doi.org/10.1038/ng0608-691

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