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A key stone cop regulates oxalate homeostasis

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A new study shows that Slc26a6-null mice manifest calcium-oxalate nephrolithiasis accompanied by enhanced net intestinal oxalate absorption. These findings point to a critical role for Slc26a6 in gastrointestinal oxalate secretion and suggest a genetic explanation for a common form of renal stone disease in humans.

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Figure 1: Simplified models of intestinal and renal proximal tubular cells depicting oxalate secretion and reabsorption pathways.

Katie Ris

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Authors and Affiliations

  1. Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, US National Institutes of Health, 10 Center Drive, Bethesda, 20982, Maryland, USA

    Robert Kleta

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  1. Robert Kleta
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Kleta, R. A key stone cop regulates oxalate homeostasis. Nat Genet 38, 403–404 (2006). https://doi.org/10.1038/ng0406-403

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