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Multiple loci on 8q24 associated with prostate cancer susceptibility

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Abstract

Previous studies have identified multiple loci on 8q24 associated with prostate cancer risk. We performed a comprehensive analysis of SNP associations across 8q24 by genotyping tag SNPs in 5,504 prostate cancer cases and 5,834 controls. We confirmed associations at three previously reported loci and identified additional loci in two other linkage disequilibrium blocks (rs1006908: per-allele OR = 0.87, P = 7.9 × 10−8; rs620861: OR = 0.90, P = 4.8 × 10−8). Eight SNPs in five linkage disequilibrium blocks were independently associated with prostate cancer susceptibility.

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Figure 1: The 8q24 region.

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Acknowledgements

Acknowledgments are presented in the Supplementary Note.

Author information

Author notes

  1. Rosalind A Eeles and Douglas F Easton: These authors contributed equally to this work.

Authors and Affiliations

  1. Cancer Research UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK

    Ali Amin Al Olama, Jonathan Morrison & Douglas F Easton

  2. The Institute of Cancer Research, Surrey, Sutton, UK

    Zsofia Kote-Jarai, Michelle Guy, Daniel A Leongamornlert, Malgorzata Tymrakiewicz, Sameer Jhavar, Ed Saunders, David P Dearnaley, Amanda L Hall, Lynne T O'Brien, Rosemary A Wilkinson, Emma Sawyer, Alan Horwich, Robert A Huddart, Vincent S Khoo, Christopher C Parker, Colin Cooper & Rosalind A Eeles

  3. Cancer Epidemiology Centre, The Cancer Council Victoria, Carlton, Victoria, Australia

    Graham G Giles & Gianluca Severi

  4. Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, The University of Melbourne, Carlton, Victoria, Australia

    Graham G Giles, Gianluca Severi, John L Hopper & Dallas R English

  5. Department of Pathology, Genetic Epidemiology Laboratory, The University of Melbourne, Parkville, Victoria, Australia

    Melissa C Southey

  6. University of Nottingham Medical School, Queens Medical Centre, Nottingham, UK

    Kenneth R Muir & Artitaya Lophatananon

  7. The Royal Marsden National Health Service Foundation Trust, Sutton, Surrey, London, UK

    David P Dearnaley, Audrey T Ardern-Jones, Amanda L Hall, Alan Horwich, Robert A Huddart, Vincent S Khoo, Christopher C Parker, Christopher J Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden & Rosalind A Eeles

  8. Department of Social Medicine, University of Bristol, Bristol, UK

    Jenny L Donovan

  9. Nuffield Department of Surgery, University of Oxford, Oxford, UK

    Freddie C Hamdy

  10. Cancer Research UK Cambridge Research Institute, Li Ka Shing Centre, Cambridge, UK

    David E Neal

  11. Departments of Oncology and Surgery, Surgical Oncology (Uro-Oncology), University of Cambridge, Addenbrooke's Hospital, Cambridge, UK

    David E Neal

Authors
  1. Ali Amin Al Olama
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  2. Zsofia Kote-Jarai
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  3. Graham G Giles
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  4. Michelle Guy
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  5. Jonathan Morrison
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  6. Gianluca Severi
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  7. Daniel A Leongamornlert
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  8. Malgorzata Tymrakiewicz
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  9. Sameer Jhavar
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  10. Ed Saunders
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  11. John L Hopper
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  12. Melissa C Southey
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  13. Kenneth R Muir
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  14. Dallas R English
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  15. David P Dearnaley
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  16. Audrey T Ardern-Jones
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  17. Amanda L Hall
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  18. Lynne T O'Brien
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  19. Rosemary A Wilkinson
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  20. Emma Sawyer
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  21. Artitaya Lophatananon
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  22. Alan Horwich
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  23. Robert A Huddart
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  24. Vincent S Khoo
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  25. Christopher C Parker
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  26. Christopher J Woodhouse
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  27. Alan Thompson
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  28. Tim Christmas
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  29. Chris Ogden
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  30. Colin Cooper
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  31. Jenny L Donovan
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  32. Freddie C Hamdy
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  33. David E Neal
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  34. Rosalind A Eeles
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  35. Douglas F Easton
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Consortia

The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology

The UK Prostate testing for cancer and Treatment study (ProtecT Study) Collaborators

Contributions

A.A.A.O. and D.F.E. performed the statistical analysis and drafted the manuscript with major input from R.A.E. and Z.K.-J. R.A.E. and D.F.E. are joint PIs on this study. M.G. provided data management for the UK Genetic Prostate Cancer Study study. J.M. provided database and bioinformatics support. G.G.G., J.L.H. and D.R.E. are principal investigators (PIs) of the Australian studies; J.L.D., F.C.H. and D.E.N. are joint PIs of ProtecT. M.C.S. led the Australian genotyping. G.S. coordinated the Australian studies. Z.K.-J coordinated the genotyping in stage 2 with support from D.A.L., M.T., S.J. and E.S. K.R.M. and R.A.E. are joint PIs of the Prostate Cancer Research Fund study. D.P.D., A.T.A.-J., A.L.H., L.T.O'B., R.A.W., E.S., A.L., A.H., R.A.H., V.S.K., C.C.P., C.J.W., A.T., T.C., C.O. and C.C. identified and collected clinical material, processed samples, undertook genotyping or collated data. Other members of The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons' Section of Oncology and The UK ProtecT Study Collaborators, listed in the Supplementary Note, collected clinical samples and provided data management support.

Corresponding author

Correspondence to Douglas F Easton.

Additional information

Full lists of members are provided in the Supplementary Note.

Full lists of members are provided in the Supplementary Note.

Supplementary information

Supplementary Text and Figures

Supplementary Tables 2–10, Supplementary Methods and Supplementary Note. (PDF 532 kb)

Supplementary Table

Supplementary Table 1 (XLS 54 kb)

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Al Olama, A., Kote-Jarai, Z., Giles, G. et al. Multiple loci on 8q24 associated with prostate cancer susceptibility. Nat Genet 41, 1058–1060 (2009). https://doi.org/10.1038/ng.452

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  • DOI: https://doi.org/10.1038/ng.452

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