Skip to main content

Advertisement

Log in

Hormone receptors in defining breast cancer prognosis—time for a rethink?

  • Viewpoint
  • Published:

From Nature Clinical Practice Oncology

View current issue Sign up to alerts

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Early Breast Cancer Trialists' Collaborative Group (2005) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365: 1687–1717

  2. Leung YK et al. (2006) Estrogen receptor (ER)- β isoforms: a key to understanding ER-β signaling. Proc Natl Acad Sci USA 103: 13162–13167

    Article  CAS  Google Scholar 

  3. Speirs V et al. (2004) Oestrogen receptor β: what it means for patients with breast cancer. Lancet Oncol 5: 174–181. Erratum in: Lancet Oncol (2004) 5: 208

    Article  CAS  Google Scholar 

  4. Palmieri C et al. (2004) The expression of ERβcx in human breast cancer and the relationship to endocrine therapy and survival. Clin Cancer Res 10: 2421–2428

    Article  CAS  Google Scholar 

  5. Esslimai-Sahla M et al. (2005) Increased estrogen receptor βcx expression during mammary carcinogenesis. Clin Cancer Res 11: 3170–3174

    Article  Google Scholar 

  6. Cui X et al. (2005) Biology of progesterone receptor loss in breast cancer and its implications for endocrine therapy. J Clin Oncol 23: 7721–7735

    Article  CAS  Google Scholar 

  7. Hopp TA et al. (2004) Low levels of estrogen receptor β protein predict resistance to tamoxifen therapy in breast cancer. Clin Cancer Res 10: 7490–7499

    Article  CAS  Google Scholar 

  8. Mote PA et al. (2002) Loss of co-ordinate expression of progesterone receptors A and B is an early event in breast carcinogenesis. Breast Cancer Res Treat 72: 163–172

    Article  CAS  Google Scholar 

  9. Loi S et al. (2007) The use of gene-expression profiling to better understand the clinical heterogeneity of estrogen receptor positive breast cancers and tamoxifen response. Crit Rev Oncol Hematol 61: 187–194

    Article  Google Scholar 

  10. Goetz MP et al. (2006) A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen. Clin Cancer Res 12: 2080–2087

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Valerie Speirs.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Speirs, V., Shaaban, A. Hormone receptors in defining breast cancer prognosis—time for a rethink?. Nat Rev Clin Oncol 4, 204–205 (2007). https://doi.org/10.1038/ncponc0771

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ncponc0771

  • Springer Nature Limited

This article is cited by

Navigation