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Natural insights for chemical biologists

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Chemical biologists studying natural-product pathways encoded in genomes have unearthed new chemistry and insights into the evolution of biologically active metabolites.

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References

  1. Schreiber, S.L. Nat. Chem. Biol. 1, 65–66 (2005).

    Article  Google Scholar 

  2. Donadio, S., Staver, M.J., McAlpine, J.B., Swanson, S.J. & Katz, L. Science 252, 675–679 (1991).

    Article  CAS  Google Scholar 

  3. Cortes, J., Haydock, S., Roberts, G.A., Bevitt, D.J. & Leadlay, P.F. Nature 348, 176–178 (1990).

    Article  CAS  Google Scholar 

  4. Katz, L. & Ashley, G. Chem. Rev. 105, 499–528 (2005).

    Article  CAS  Google Scholar 

  5. Schwarzer, D. Firking, R., Marahiel, M.A. Nat. Prod. Rep. 20, 275–287 (2003).

    Article  CAS  Google Scholar 

  6. Tang, L. et al. J. Antibiot. (Tokyo) 58, 178–184 (2005).

    Article  CAS  Google Scholar 

  7. Lowden, P.A., Bohm, G.A., Metcalfe, S., Staunton, J. & Leadlay, P.F. ChemBioChem 5, 535–538 (2004).

    Article  CAS  Google Scholar 

  8. Weber, G., Shorgendorfer, K., Schneider-Scherzer, E. & Leitner, E. Curr. Genet. 26, 120–125 (1994).

    Article  CAS  Google Scholar 

  9. Hubbard, B.K. & Walsh, C.T. Angew. Chem. Int. Edn Engl. 42, 730–765 (2003).

    Article  CAS  Google Scholar 

  10. Liu, W., Christensen, S., Standage, S. & Shen, B. Science 297, 1170–1173 (2002).

    Article  CAS  Google Scholar 

  11. Walsh, C. Science 303, 1805–1810 (2004).

    Article  CAS  Google Scholar 

  12. McDaniel, R. et al. Proc. Natl. Acad. Sci. USA 96, 1846–1851 (1999).

    Article  CAS  Google Scholar 

  13. Auclair, K. et al. J. Am. Chem. Soc. 122, 11519–11520 (2000).

    Article  CAS  Google Scholar 

  14. O'Connor, S., Chen, H. & Walsh, C. Biochemistry 41, 5685–5694 (2002).

    Article  CAS  Google Scholar 

  15. Vaillancourt, F., Yeh, E., Vosburg, D., O'Connor, S. & Walsh, C. Nature (in the press) (2005).

    Google Scholar 

  16. Clardy, J. & Walsh, C. Nature 432, 829–837 (2004).

    Article  CAS  Google Scholar 

  17. Liu, H.W. & Thorson, J.S. Annu. Rev. Microbiol. 48, 223–256 (1994).

    Article  CAS  Google Scholar 

  18. Losey, H.C. et al. Walsh, C. Biochemistry 40, 4745–4755 (2001).

    Article  CAS  Google Scholar 

  19. Freel Meyers, C., Oberthur, M., Heide, L., Kahne, D. & Walsh, C. Biochemistry 43, 15022–15036 (2004).

    Article  Google Scholar 

  20. Lu, W. et al. Chem. Biol. 12, 527–534 (2005).

    Article  CAS  Google Scholar 

  21. Walsh, C., Freel Meyers, C. & Losey, H.C. J. Med. Chem. 46, 3425–3436 (2003).

    Article  CAS  Google Scholar 

  22. Koehn, F.E. & Carter, G.T. Nat. Rev. Drug Discov. 4, 206–220 (2005).

    Article  CAS  Google Scholar 

  23. Omura, S. et al. Proc. Natl. Acad. Sci. USA 98, 12215–12220 (2001).

    Article  CAS  Google Scholar 

  24. Zazopoulos, E. et al. Nat. Biotechnol. 21, 187–190 (2003).

    Article  CAS  Google Scholar 

  25. Handelsman, J. Microbiol. Mol. Biol. Rev. 68, 669–685 (2004).

    Article  CAS  Google Scholar 

  26. Brady, S., Chao, C.J. & Clardy, J. J. Am. Chem. Soc. 124, 9968–9969 (2002).

    Article  CAS  Google Scholar 

  27. Walsh, C. Posttranslational Modification of Proteins: Expanding Nature's Inventory (Roberts & Co Press, Englewood, Colorado, USA, 2005).

    Google Scholar 

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Acknowledgements

I thank M. Fischbach for the artwork in this Commentary.

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Walsh, C. Natural insights for chemical biologists. Nat Chem Biol 1, 122–124 (2005). https://doi.org/10.1038/nchembio0805-122

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