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Antigenic peptides

Reviving nuclear translation

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Noncanonical translation of prespliced mRNA provides physiological meaning to nuclear translation in generating antigenic peptide substrates for the endogenous major histocompatibility complex class I pathway.

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Figure 1: Model for antigenic MHC class I peptide substrate generation.

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Author information

Authors and Affiliations

  1. Petra Van Damme is at the Department of Medical Protein Research, and the Department of Biochemistry, VIB, Ghent, Belgium, Ghent University, Ghent, Belgium.,

    Petra Van Damme

  2. Department of Mathematical Modeling, Gerben Menschaert is at the Laboratory for Bioinformatics and Computational Genomics, Statistics and Bioinformatics, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium.,

    Gerben Menschaert

Authors
  1. Petra Van Damme
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  2. Gerben Menschaert
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Correspondence to Petra Van Damme.

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The authors declare no competing financial interests.

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Van Damme, P., Menschaert, G. Reviving nuclear translation. Nat Chem Biol 9, 759–760 (2013). https://doi.org/10.1038/nchembio.1394

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