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Enzyme dynamics

Control of active-site compression

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Compression of the active sites of enzymes has been linked to the bulk of amino acid side chains, but now experiments highlight that the harder we look, the more curious the relationship between protein structure and function becomes.

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Figure 1: Selected features of hydrogen tunnelling during C–H activation in enzymes.
Figure 2: Experimental results that highlight the differences between the wild-type and mutant enzymes measured by Scrutton and co-workers2.

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Authors and Affiliations

  1. Judith P. Klinman is in the Department of Chemistry, Department of Molecular and Cell Biology, and the California Institute for Quantitative Biosciences, Berkeley, University of California, California 94720-3220, USA. klinman@berkeley.edu,

    Judith P. Klinman

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  1. Judith P. Klinman
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Klinman, J. Control of active-site compression. Nature Chem 2, 907–909 (2010). https://doi.org/10.1038/nchem.886

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