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Biophysical chemistry

Strength in numbers

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Replication of the HIV-1 viral genome can be inhibited by a protein known as APOBEC3G, via two seemingly contradictory mechanisms. Now, the molecular conundrum behind these two processes has been resolved.

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Figure 1: Schematic of the proposed model for the binding of A3G to single-stranded DNA in vitro3.

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Authors and Affiliations

  1. Graeme A. King and Gijs J. L. Wuite are in the Department of Physics and Astronomy, VU University Amsterdam, De Boelelaan 1081, 1081 HV, Amsterdam, The Netherlands,

    Graeme A. King & Gijs J. L. Wuite

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  1. Graeme A. King
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  2. Gijs J. L. Wuite
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Correspondence to Graeme A. King or Gijs J. L. Wuite.

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King, G., Wuite, G. Strength in numbers. Nature Chem 6, 13–14 (2014). https://doi.org/10.1038/nchem.1831

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