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Mitochondria link metabolism and epigenetics in haematopoiesis

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Due to their varied metabolic and signalling roles, mitochondria are important in mediating cell behaviour. By altering mitochondrial function, two studies now identify metabolite-induced epigenetic changes that have profound effects on haematopoietic stem cell fate and function.

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Figure 1: Mitochondrial regulation of haematopoiesis.

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Authors and Affiliations

  1. Department of Biochemistry and Howard Hughes Medical Institute, University of Utah School of Medicine, 15 North Medical Drive East, Room 5520A, Salt Lake City, 84112-5650, Utah, USA

    John C. Schell & Jared Rutter

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  1. John C. Schell
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  2. Jared Rutter
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Correspondence to Jared Rutter.

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The authors declare no competing financial interests.

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Schell, J., Rutter, J. Mitochondria link metabolism and epigenetics in haematopoiesis. Nat Cell Biol 19, 589–591 (2017). https://doi.org/10.1038/ncb3540

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