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Locking in on the human methylome

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Two groups have combined padlock probes and massively parallel sequencing to characterize cytosine methylation in targeted regions of the human genome.

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Figure 1: High-throughput analysis of genomic methylation using padlock probes and bisulfite-treated DNA3,4 or methylation-sensitive cut counting4.

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Authors and Affiliations

  1. Benjamin P. Berman, Daniel J. Weisenberger and Peter W. Laird are at the USC Epigenome Center, University of Southern California, Keck School of Medicine, Los Angeles, California, USA. plaird@usc.edu,

    Benjamin P Berman, Daniel J Weisenberger & Peter W Laird

Authors
  1. Benjamin P Berman
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  2. Daniel J Weisenberger
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  3. Peter W Laird
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Competing interests

P.W.L. is a Scientific Advisory Board member and consultant for Epigenomics, AG, which has a commercial interest in DNA methylation diagnostics.

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Berman, B., Weisenberger, D. & Laird, P. Locking in on the human methylome. Nat Biotechnol 27, 341–342 (2009). https://doi.org/10.1038/nbt0409-341

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