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Generation of the potent anti-malarial drug artemisinin in tobacco

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Figure 1: The pathway and constructs for engineering artemisinin production in tobacco.
Figure 2: Production of artemisinin in engineered tobacco plants.

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Acknowledgements

We thank I. Kaye for his support and assistance. This work was partially funded by the Israel Science Foundation grant nos. 269/09 and 432/10, F.I.R.S.T. 432/10 and BARD grant no. US-4322-10. A.V. is an incumbent of the Wolfson Chair in Floriculture.

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Authors and Affiliations

  1. Institute of Plant Sciences and Genetics in Agriculture, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel

    Moran Farhi, Elena Marhevka, Julius Ben-Ari, Orit Edelbaum, Ben Spitzer-Rimon & Alexander Vainstein

  2. Department of Biochemistry, Food Science and Nutrition, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot, Israel

    Anna Algamas-Dimantov, Hagai Abeliovich & Betty Schwartz

  3. Department of Molecular, Cellular and Developmental Biology, The University of Michigan, Ann Arbor, Michigan, USA

    Zhuobin Liang, Vardit Zeevi & Tzvi Tzfira

  4. Department of Life Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel

    Tzvi Tzfira

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  1. Moran Farhi
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  2. Elena Marhevka
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  3. Julius Ben-Ari
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  4. Anna Algamas-Dimantov
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  11. Tzvi Tzfira
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  12. Alexander Vainstein
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Correspondence to Alexander Vainstein.

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Supplementary Methods and Supplementary Fig. 1 (PDF 711 kb)

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Farhi, M., Marhevka, E., Ben-Ari, J. et al. Generation of the potent anti-malarial drug artemisinin in tobacco. Nat Biotechnol 29, 1072–1074 (2011). https://doi.org/10.1038/nbt.2054

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