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Re-evaluating evolution in the HIV reservoir

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Figure 1: For the first six months of ART, the persistent latent reservoir makes up a minority of sampled sequences.
Figure 2: Simulated decay of labile infected cell population creates misleading appearance of viral replication and evolution in first six months of treatment.

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Author information

Authors and Affiliations

  1. Department of Biomedical Informatics, Columbia University Medical Center, New York, New York, USA

    Daniel I. S. Rosenbloom

  2. Program for Evolutionary Dynamics, Harvard University, Cambridge, Massachusetts, USA

    Alison L. Hill

  3. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    Sarah B. Laskey & Robert F. Siliciano

  4. Howard Hughes Medical Institute, Baltimore, Maryland, USA

    Robert F. Siliciano

Authors
  1. Daniel I. S. Rosenbloom
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  2. Alison L. Hill
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  3. Sarah B. Laskey
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  4. Robert F. Siliciano
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Contributions

Wrote the manuscript: D.I.S.R., A.L.H., S.B.L., R.F.S. Simulations and phylogenetic analyses: D.I.S.R., A.L.H., R.F.S. Estimation of labile compartments: S.B.L., R.F.S.

Corresponding author

Correspondence to Robert F. Siliciano.

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Competing interests

The authors declare no competing financial interests.

Extended data figures and tables

Extended Data Table 1 Analysis of post-treatment simulated samples based on sequences obtained before treatment14
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Supplementary Information

This file contains Supplementary Methods and Supplementary References. (PDF 428 kb)

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Supplementary Data

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Supplementary Data

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Rosenbloom, D., Hill, A., Laskey, S. et al. Re-evaluating evolution in the HIV reservoir. Nature 551, E6–E9 (2017). https://doi.org/10.1038/nature24634

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  • DOI: https://doi.org/10.1038/nature24634

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