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GATM locus does not replicate in rhabdomyolysis study

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A Brief Communications Arising to this article was published on 17 September 2014

Abstract

Arising from L. M. Mangravite et al. Nature 502, 377–380 (2013); doi:10.1038/nature12508

All HMG-CoA reductase inhibitors (statins) can cause muscle injury ranging from asymptomatic elevations in creatine kinase levels to severe muscle breakdown (rhabdomyolysis) leading to kidney failure and death1, and the genetic variants responsible for this uncommon adverse drug reaction remain largely undiscovered. Mangravite et al. reported a new locus in the gene GATM (rs9806699) that was associated with a decreased risk of muscle injury in two case-control studies of myopathy (odds ratio, 0.60)2. In a larger case-control study of statin-related rhabdomyolysis, a more severe form of muscle injury, we were unable to replicate this finding. This failure to replicate raises questions about the role of GATM in statin-related muscle injury. There is a Reply to this Brief Communication Arising by Mangravite, L. M. et al. Nature 513, http://dx.doi.org/10.1038/nature13630 (2014).

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Authors and Affiliations

  1. Cardiovascular Health Research Unit, University of Washington, 1730 Minor Avenue, Suite 1360, Seattle, Washington 98101, USA,

    James S. Floyd, Joshua C. Bis, Jennifer A. Brody, Susan R. Heckbert, Kenneth Rice & Bruce M. Psaty

  2. Department of Medicine, University of Washington, 1959 Northeast Pacific Street, Box 356420, Seattle, Washington 98195-6420, USA,

    James S. Floyd, Joshua C. Bis, Jennifer A. Brody & Bruce M. Psaty

  3. Department of Epidemiology, University of Washington, 1959 Northeast Pacific Street, Box 357236, Seattle, Washington 98195-7236, USA,

    Susan R. Heckbert & Bruce M. Psaty

  4. Group Health Research Institute, Group Health Cooperative, 1730 Minor Avenue, Suite 1600, Seattle, 98101-1448, Washington, USA

    Susan R. Heckbert & Bruce M. Psaty

  5. Department of Biostatistics, University of Washington, 1959 Northeast Pacific Street, Box 357232, Seattle, Washington 98195-7323, USA,

    Kenneth Rice

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  1. James S. Floyd
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  2. Joshua C. Bis
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  3. Jennifer A. Brody
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  4. Susan R. Heckbert
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  5. Kenneth Rice
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  6. Bruce M. Psaty
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Contributions

J.C.B. and J.S.F. carried out the analyses. B.M.P. obtained the funding for this work. J.S.F., F.C.B., J.A.B., S.R.H., K.R. and B.M.P. contributed to the design of the analyses and the drafting and revision of the manuscript.

Corresponding author

Correspondence to James S. Floyd.

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Competing interests

B.M.P. serves on the data and safety monitoring board (DSMB) for a clinical trial of a device funded by the manufacturer (Zoll LifeCor).

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Floyd, J., Bis, J., Brody, J. et al. GATM locus does not replicate in rhabdomyolysis study. Nature 513, E1–E3 (2014). https://doi.org/10.1038/nature13629

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