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Metabolite turns master regulator

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The phenomenon of catabolite repression enables microorganisms to use their favourite carbon source first. New work reveals α-ketoacids as key effectors of this process, with their levels regulating gene expression. See Article p.301

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Figure 1: Regulation of cAMP levels by carbon and nitrogen availability.

Notes

  1. *This article and the paper under discussion3 were published online on 7 August 2013.

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Authors and Affiliations

  1. Joshua D. Rabinowitz is in the Department of Chemistry and at the Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA.,

    Joshua D. Rabinowitz

  2. Thomas J. Silhavy is in the Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA.,

    Thomas J. Silhavy

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  1. Joshua D. Rabinowitz
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  2. Thomas J. Silhavy
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Correspondence to Joshua D. Rabinowitz.

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Rabinowitz, J., Silhavy, T. Metabolite turns master regulator. Nature 500, 283–284 (2013). https://doi.org/10.1038/nature12544

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