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Bioinorganic chemistry

Enzymes activated by synthetic components

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Synthetic analogues of the catalytic subsite of the hydrogen-producing enzyme HydA1 have been disappointingly inactive. The incorporation of such analogues into the enzyme's active site reveals the requirements for activity. See Letter p.66

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Figure 1: Assembly line interrupted.

Notes

  1. *This article and the paper under discussion1 were published online on 26 June 2013.

References

  1. Berggren, G. et al. Nature 499, 66–69 (2013).

    Article  ADS  CAS  Google Scholar 

  2. Cendron, L. et al. J. Biol. Chem. 286, 43944–43950 (2011).

    Article  CAS  Google Scholar 

  3. Mulder, D. W. et al. Nature 465, 248–252 (2010).

    Article  ADS  CAS  Google Scholar 

  4. Nicolet, Y., Piras, C., Legrand, P., Hatchikian, C. E. & Fontecilla-Camps, J. C. Structure 7, 13–23 (1999).

    Article  CAS  Google Scholar 

  5. Nicolet, Y., Amara, P., Mouesca, J.-M. & Fontecilla-Camps, J. C. Proc. Natl Acad. Sci. USA 106, 14867–14871 (2009).

    Article  ADS  CAS  Google Scholar 

  6. Posewitz, M. C. et al. J. Biol. Chem. 279, 25711–25720 (2004).

    Article  CAS  Google Scholar 

  7. Shepard, E. M. et al. Proc. Natl Acad. Sci. USA 107, 10448–10453 (2010).

    Article  ADS  CAS  Google Scholar 

  8. Kuchenreuther, J. M., Britt, R. D. & Swartz, J. R. PLoS ONE 7, e45850 (2012).

    Article  ADS  CAS  Google Scholar 

  9. Bethel, R. D., Singleton, M. L. & Darensbourg, M. Y. Angew. Chem. Int. Edn 49, 8567–8569 (2010).

    Article  CAS  Google Scholar 

  10. Ohashi, M. et al. Angew. Chem. Int. Edn 42, 1005–1008 (2003).

    Article  CAS  Google Scholar 

  11. Carey, J. R. et al. J. Am. Chem. Soc. 126, 10812–10813 (2004).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Ryan D. Bethel and Marcetta Y. Darensbourg are in the Department of Chemistry, Texas A&M University, College Station, Texas 77843, USA.,

    Ryan D. Bethel & Marcetta Y. Darensbourg

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  1. Ryan D. Bethel
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  2. Marcetta Y. Darensbourg
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Correspondence to Ryan D. Bethel or Marcetta Y. Darensbourg.

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Bethel, R., Darensbourg, M. Enzymes activated by synthetic components. Nature 499, 40–41 (2013). https://doi.org/10.1038/nature12260

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