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Sorting out the sirtuins

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Debates over the role of sirtuin proteins in ageing are maturing into functional assessments of the individual proteins. It seems that overexpression of a specific sirtuin can extend lifespan in male mice. See Letter p.218

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Figure 1: Potential mechanisms of action of SIRT6 on longevity.

Notes

  1. *This article and the paper3 under discussion were published online on 22 February 2012.

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Authors and Affiliations

  1. David B. Lombard and Richard A. Miller are in the Department of Pathology and the Geriatrics Center, University of Michigan School of Medicine, Ann Arbor, Michigan 48100-2200, USA.,

    David B. Lombard & Richard A. Miller

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  1. David B. Lombard
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  2. Richard A. Miller
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Correspondence to David B. Lombard or Richard A. Miller.

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Lombard, D., Miller, R. Sorting out the sirtuins. Nature 483, 166–167 (2012). https://doi.org/10.1038/nature10950

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