Abstract
Martin and Mundy1 emphasize the crucial role played by osteoclasts in the metastasis of many tumour types to bone. Our intention was not to question the importance of osteoclasts in bone metastases, but rather to show that RANK ligand (RANKL) exerts additional action on cancer cells beyond its effects on osteoclasts2. We reported that epithelial tumour cells can express RANK, a finding that is supported by earlier work3; that RANKL has chemotactic activity4; and that in vivo inhibition of RANKL by osteoprotegerin reduces tumour burden in bone when assessed in a previously published experimental system5.
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Jones, D., Nakashima, T., Sanchez, O. et al. Can osteoclasts be excluded? (Reply). Nature 445, E19–E20 (2007). https://doi.org/10.1038/nature05658
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DOI: https://doi.org/10.1038/nature05658
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