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Does gut hormone PYY3–36 decrease food intake in rodents? (reply)

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Abstract

The results of Tschöp et al.1 on the lack of effect of peripheral administration of PYY3–36 on food intake in rodents are at odds with both the published literature2,3,4,5,6,7,8 (our Table 1) and with earlier data generated by the Tschöp laboratory.

Table 1 Summary of literature data on PYY3–36 and food intake in rodents
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References

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Authors and Affiliations

  1. Imperial College Faculty of Medicine at Hammersmith Campus, London, W12 0NN, UK

    R. L. Batterham, M. A. Cowley, C. J. Small, H. Herzog, M. A. Cohen, C. L. Dakin, A. M. Wren, A. E. Brynes, M. J. Low, M. A. Ghatei, R. D. Cone & S. R. Bloom

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  1. R. L. Batterham
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  2. M. A. Cowley
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  3. C. J. Small
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  4. H. Herzog
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  5. M. A. Cohen
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  6. C. L. Dakin
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  7. A. M. Wren
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  8. A. E. Brynes
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  9. M. J. Low
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  10. M. A. Ghatei
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  11. R. D. Cone
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  12. S. R. Bloom
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Corresponding author

Correspondence to S. R. Bloom.

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Competing interests

R.L.B., M.A.C., C.J.S., M.A.G. and S.R.B. have a financial interest in technology licensed to Thiakis, a company that may have a commercial interest in the results of this research and technology. M.A.C. has a significant financial interest in Orexigen Therapeutics, a company that may have a commercial interest in the results of this research and technology. This potential conflict of interest has been reviewed and managed by the OHSU Conflict of Interest in Research Committee. R.D.C. is a significant shareholder in Neurocrine Biosciences, chief scientific officer of and a significant shareholder in Znomics, and a co-inventor on patents dealing with PYY, licensed to Orexigen and other biotechnology companies. H.H., M.A.C., C.L.D., A.M.W., A.E.B. and M.J.L. have no conflicts of interest.

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Batterham, R., Cowley, M., Small, C. et al. Does gut hormone PYY3–36 decrease food intake in rodents? (reply). Nature 430, 3–4 (2004). https://doi.org/10.1038/nature02666

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