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Genotoxic stresses promote clonal expansion of hematopoietic stem cells expressing mutant p53

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Acknowledgements

This work was supported in part by a NIH/NIA R56 award R56AG052501, a Department of Defense (DoD) Grant W81XWH-13-1-0187, a Career Development Award from the St. Baldrick’s Foundation, an Elsa Pardee Foundation New Investigator Award, a Leukemia Research Foundation New Investigator Award, a Showalter Trust Fund New Investigator Award, an Alex Lemonade Stand Foundation grant, a Children’s Leukemia Research Association grant and an American Cancer Society Institutional Research Grant to YL. We thank the Flow Cytometry Core and In vivo Therapeutic Core Laboratories, which were sponsored, in part, by the NIDDK Cooperative Center of Excellence in Hematology (CCEH) grant U54 DK106846. This work was supported, in part, by a Project Development Team within the ICTSI NIH/NCRR Grant Number UL1TR001108. We also thank Dr. Yang Xu at USCD for providing the p53R248W mice to the study.

Author contributions

SC and YL designed the research. SC, RG, CY, MK and SZL performed the research. SC and YL analyzed the data and performed the statistical analysis. MCY, HB, RK, HSB and LDM provided reagents and/or input to the study. SC and YL wrote the manuscript. All authors read, commented on and approved the manuscript.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA

    S Chen, L D Mayo & Y Liu

  2. Department of Pediatrics, Herman B Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN, USA

    R Gao, C Yao, M Kobayashi, S Z Liu, M C Yoder, R Kapur, L D Mayo & Y Liu

  3. Department of Rheumatism, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China

    C Yao

  4. Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN, USA

    H Broxmeyer

  5. Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA

    H S Boswell

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  1. S Chen
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  2. R Gao
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  3. C Yao
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  4. M Kobayashi
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  11. Y Liu
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Corresponding author

Correspondence to Y Liu.

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Chen, S., Gao, R., Yao, C. et al. Genotoxic stresses promote clonal expansion of hematopoietic stem cells expressing mutant p53. Leukemia 32, 850–854 (2018). https://doi.org/10.1038/leu.2017.325

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