Skip to main content
Log in

A recurrent immunophenotype at diagnosis independently identifies high-risk pediatric acute myeloid leukemia: a report from Children’s Oncology Group

  • Letter to the Editor
  • Published:
Leukemia Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1
Figure 2

References

  1. Pui CH, Carroll WL, Meshinchi S, Arceci RJ . Biology, risk stratification and therapy of pediatric acute leukemias: an update. J Clin Oncol 2011; 29: 551–565.

    Article  Google Scholar 

  2. Meshinchi S . Hematopoietic cell transplantatin in high-risk childhood acute myelogenous leukemia. Biol Blood Marrow Transplant 2013; 19: 1002–1003.

    Article  Google Scholar 

  3. Tarlock K, Meshinchi S . Pediatric acute myeloid leukemia: biology and therapeutic implications of genomic variants. Pediatr Clin North Am 2015; 62: 75–93.

    Article  Google Scholar 

  4. Loken MR, Alonzo TA, Pardo L, Gerbing RB, Raimondi SC, Hirsch BA et al. Residual disease detected by multidimensional flow cytometry signifies high relapse risk in patients with de novo acute myeloid leukemia: a report from Children’s Oncology Group. Blood 2012; 120: 1581–1588.

    Article  Google Scholar 

  5. Casasnovas RO, Slimane FK, Garand R, Faure GC, Campos L, Deneys V et al. Immunological classification of acute myeloblastic leukemias: relevance to patient outcome. Leukemia 2003; 17: 515–527.

    Article  CAS  Google Scholar 

  6. Legrand O, Perrot JY, Baudard M, Cordier A, Lautier R, Simonin G et al. The immunophenotype of 177 adults with acute myeloid leukemia: proposal of a prognostic score. Blood 2000; 96: 870–877.

    CAS  PubMed  Google Scholar 

  7. Iriyama N, Asou N, Miyazaki Y, Yamaguchi S, Sato S, Sakura T et al. Normal karyotype acute myeloid leukemia with the CD7+ CD15+ CD34+ HLA-DR+immunophenotype is a clinically distinct entity with a favorable outcome. Ann Hematol 2014; 96: 957–963.

    Article  Google Scholar 

  8. Scott AA, Head DR, Kopecky KJ, Appelbaum FR, Theil KS, Grever MR et al. HLA-DR-, CD33+, CD56+, CD16- myeloid/natural killer cell acute leukemia: a previously unrecognized form of acute leukemia potentially misdiagnosed as French-American-British acute myeloid leukemia-M3. Blood 1994; 84: 244–255.

    CAS  PubMed  Google Scholar 

  9. Gamis AS, Alonzo TA, Meshinchi S, Sung L, Gerbing RB, Raimondi SC et al. Gemtuzumab ozogamicin in children and adolescents with de novo acute myeloid leukemia improves event-free survival by reducing relapse risk: Results from the randomized phase III Children's Oncology Group trial AAML0531. J Clin Oncol 2014; 32: 3021–3032.

    Article  CAS  Google Scholar 

  10. Alegretti AP, Bittar CM, Bittencourt R, Piccoli AK, Schneider L, Silla LM et al. The expression of CD56 antigen is associated with poor prognosis in patients with acute myeloid leukemia. Rev Bras Hematol Hemoter 2011; 33: 202–206.

    Article  Google Scholar 

  11. Raspadori D, Damiani D, Lenoci M, Rondelli D, Testoni N, Nardi G et al. CD56 antigenic expression in acute myeloid leukemia identifies patients with poor clinical prognosis. Leukemia 2001; 15: 1161–1164.

    Article  CAS  Google Scholar 

  12. Urosevic M, Conrad C, Kamarashev J, Asagoe K, Cozzio A, Burg G et al. CD4+CD56+ hematodermic neoplasms bear a plasmacytoid dendritic cell phenotype. Hum Pathol 2005; 36: 1020–1024.

    Article  CAS  Google Scholar 

  13. Meshinchi S, Alonzo TA, Stirewalt DL, Zwaan M, Zimmerman M, Reinhardt D et al. Clinical implications of FLT3 mutations in pediatric AML. Blood 2006; 108: 3654–3661.

    Article  CAS  Google Scholar 

  14. Tarlock K, Alonzo TA, Moraleda PP, Gerbing RB, Raimondi SC, Hirsch BA et al. Acute myeloid leukaemia (AML) with t(6;9)(p23;q34) is associated with poor outcome in childhood AML regardless of FLT3-ITD status: a report from the Children's Oncology Group. Br J Haematol 2014; 166: 254–259.

    Article  Google Scholar 

  15. Johnston DL, Alonzo TA, Gerbing RB, Hirsh B, Heerema NA, Ravindranath Y et al. Outcome of pediatric patients with acute myeloid leukemia (AML) and -5/5q- abnormalities from five pediatric AML treatment protocols: a report from the Children's Oncology Group. Pediatr Blood Cancer 2013; 60: 2073–2078.

    Article  Google Scholar 

Download references

Acknowledgements

We would like to thank the patients and families for participating in AAML0531. Particularly we would like to thank the family of the index patient for the permission to name the adverse prognostic phenotype RAM. Documentation of informed consent is on record with the Children’s Oncology Group and with HematoLogics Inc. This work was supported by grants U10CA098543 (Chair’s grant), U10CA098413 (the Statistical Center Grant), U10CA180886 (National Clinical Trials Network Operations Center Grant), U10CA180899 (National Clinical Trials Network Statistics and Data Center) and U10CA180886 (Biomarker, Imaging and Quality of Life Studies Funding Program). The trial was registered at www.clinicaltrials.gov as NCT00372593.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to L Eidenschink Brodersen.

Ethics declarations

Competing interests

LEB, AJM, LP, APV and MRL are employed by Hematologics, Inc. MRL is an equity owner of Hematologics, Inc.

Additional information

Supplementary Information accompanies this paper on the Leukemia website

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Eidenschink Brodersen, L., Alonzo, T., Menssen, A. et al. A recurrent immunophenotype at diagnosis independently identifies high-risk pediatric acute myeloid leukemia: a report from Children’s Oncology Group. Leukemia 30, 2077–2080 (2016). https://doi.org/10.1038/leu.2016.119

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/leu.2016.119

  • Springer Nature Limited

This article is cited by

Navigation