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Diet-induced obesity promotes a myeloma-like condition in vivo

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References

  1. Fowler JA, Lwin ST, Drake MT, Edwards JR, Kyle RA, Mundy GR et al. Host-derived adiponectin is tumor-suppressive and a novel therapeutic target for multiple myeloma and the associated bone disease. Blood 2011; 118: 5872–5882.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Landgren O, Rajkumar SV, Pfeiffer RM, Kyle RA, Katzmann JA, Dispenzieri A et al. Obesity is associated with an increased risk of monoclonal gammopathy of undetermined significance (MGUS) among African-American and Caucasian women. Blood 2010; 116: 1056–1059.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Wallin A, Larsson SC . Body mass index and risk of multiple myeloma: a meta-analysis of prospective studies. Eur J Cancer 2011; 47: 1606–1615.

    Article  PubMed  Google Scholar 

  4. Carson KR, Bates ML, Tomasson MH . The skinny on obesity and plasma cell myeloma: a review of the literature. Bone Marrow Transplant 2014; 49: 1009–1015.

    Article  CAS  PubMed  Google Scholar 

  5. Teras LR, Kitahara CM, Birmann BM, Hartge PA, Wang SS, Robien K et al. Body size and multiple myeloma mortality: a pooled analysis of 20 prospective studies. Br J Haematol 2014; 166: 667–676.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Hofmann JN, Moore SC, Lim U, Park Y, Baris D, Hollenbeck AR et al. Body mass index and physical activity at different ages and risk of multiple myeloma in the NIH-AARP diet and health study. Am J Epidemiol 2013; 177: 776–786.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Murphy F, Kroll ME, Pirie K, Reeves G, Green J, Beral V . Body size in relation to incidence of subtypes of haematological malignancy in the prospective Million Women Study. Br J Cancer 2013; 108: 2390–2398.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Radl J, Croese JW, Zurcher C, Van den Enden-Vieveen MH, de Leeuw AM . Animal model of human disease. Multiple myeloma. Am J Pathol 1988; 132: 593–597.

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Fowler JA, Mundy GR, Lwin ST, Edwards CM . Bone marrow stromal cells create a permissive microenvironment for myeloma development: a new stromal role for Wnt inhibitor Dkk1. Cancer Res 2012; 72: 2183–2189.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Kyle RA, Rajkumar SV . Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma. Hematol Oncol Clin North Am 2007; 21: 1093–1113.

    Article  Google Scholar 

  11. Ng AC, Khosla S, Charatcharoenwitthaya N, Kumar SK, Achenbach SJ, Holets MF et al. Bone microstructural changes revealed by high-resolution peripheral quantitative computed tomography imaging and elevated DKK1 and MIP-1alpha levels in patients with MGUS. Blood 2011; 118: 6529–6534.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Coleman DL, Hummel KP . The influence of genetic background on the expression of the obese (Ob) gene in the mouse. Diabetologia 1973; 9: 287–293.

    Article  CAS  Google Scholar 

  13. Ribeiro AM, Andrade S, Pinho F, Monteiro JD, Costa M, Lopes C et al. Prostate cancer cell proliferation and angiogenesis in different obese mice models. Int J Exp Pathol 2010; 91: 374–386.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Georgii-Hemming P, Wiklund HJ, Ljunggren O, Nilsson K . Insulin-like growth factor I is a growth and survival factor in human multiple myeloma cell lines. Blood 1996; 88: 2250–2258.

    CAS  PubMed  Google Scholar 

  15. Beason TS, Chang SH, Sanfilippo KM, Luo S, Colditz GA, Vij R et al. Influence of body mass in dex on survival in veterans with multiple myeloma. Oncologist 2013; 18: 1074–1079.

    Article  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

This work was supported by the National Cancer Institute through R01-CA137116, an American Society of Bone and Mineral Research Career Establishment Award and a Marie Curie Career Integration Grant within the 7th European Community Framework Programme.

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Author notes

  1. S T Lwin and S W Z Olechnowicz: These authors contributed equally to this work.

Authors and Affiliations

  1. Nuffield Department of Surgical Sciences, University of Oxford, Oxford, UK

    S T Lwin, S W Z Olechnowicz & C M Edwards

  2. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Botnar Research Centre, University of Oxford, Oxford, UK

    S T Lwin & C M Edwards

  3. Vanderbilt Center for Bone Biology, Vanderbilt University, Nashville, TN, USA

    S T Lwin, J A Fowler & C M Edwards

Authors
  1. S T Lwin
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  2. S W Z Olechnowicz
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  3. J A Fowler
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  4. C M Edwards
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Corresponding author

Correspondence to C M Edwards.

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The authors declare no conflict of interest.

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Lwin, S., Olechnowicz, S., Fowler, J. et al. Diet-induced obesity promotes a myeloma-like condition in vivo. Leukemia 29, 507–510 (2015). https://doi.org/10.1038/leu.2014.295

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