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Dll1/Notch activation accelerates multiple myeloma disease development by promoting CD138+ MM-cell proliferation

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References

  1. Kopan R, Ilagan MX . The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 2009; 137: 216–233.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Nefedova Y, Cheng P, Alsina M, Dalton WS, Gabrilovich DI . Involvement of Notch-1 signaling in bone marrow stroma-mediated de novo drug resistance of myeloma and other malignant lymphoid cell lines. Blood 2004; 103: 3503–3510.

    Article  CAS  PubMed  Google Scholar 

  3. Jundt F, Probsting KS, Anagnostopoulos I, Muehlinghaus G, Chatterjee M, Mathas S et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Blood 2004; 103: 3511–3515.

    Article  CAS  PubMed  Google Scholar 

  4. Ghoshal P, Nganga AJ, Moran-Giuati J, Szafranek A, Johnson TR, Bigelow AJ et al. Loss of the SMRT/NCoR2 corepressor correlates with JAG2 overexpression in multiple myeloma. Cancer Res 2009; 69: 4380–4387.

    Article  CAS  PubMed  Google Scholar 

  5. Nefedova Y, Landowski TH, Dalton WS . Bone marrow stromal-derived soluble factors and direct cell contact contribute to de novo drug resistance of myeloma cells by distinct mechanisms. Leukemia 2003; 17: 1175–1182.

    Article  CAS  PubMed  Google Scholar 

  6. Zweidler-McKay PA, He Y, Xu L, Rodriguez CG, Karnell FG, Carpenter AC et al. Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies. Blood 2005; 106: 3898–3906.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Vanderkerken K, Asosingh K, Croucher P, Van Camp B . Multiple myeloma biology: lessons from the 5TMM models. Immunol Rev 2003; 194: 196–206.

    Article  CAS  Google Scholar 

  8. Armstrong F, Brunet P, Gerby B, Rouyez MC, Calvo J, Fontenay M et al. NOTCH is a key regulator of human T-cell acute leukemia initiating cell activity. Blood 2009; 113: 1730–1740.

    Article  CAS  Google Scholar 

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Acknowledgements

We would like to thank Dr Françoise Pflumio from the Université Paris Descartes, France, for her kindness of donating the MS5 and MS5.Dll1 stromal cell lines for our research. We also thank Angelo Willems and Carine Seynaeve for their expert technical assistance. Our research work is supported by grants from CSC-VUB Scholarship, European Union (MSCNET, LSHC-CT-2006-037602) and Over-Myr (EU-FP7), Vlaamse Kankerliga and Fonds voor Wetenschappelijk Onderzoek-Vlaanderen (FWO). Eline Menu, Elke De Bruyne and Els Van Valckenborgh are post-doctoral fellows of FWO.

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Author notes

  1. K Vanderkerken and E Van Valckenborgh: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Hematology and Immunology-Myeloma Center Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium

    D Xu, J Hu, S Xu, E De Bruyne, E Menu, B Van Camp, K Vanderkerken & E Van Valckenborgh

  2. Department of Molecular Biology and Genetics, Medical School of Xi’an Jiaotong University, Xi’an, China

    D Xu & J Hu

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  1. D Xu
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  2. J Hu
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  3. S Xu
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  4. E De Bruyne
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  8. E Van Valckenborgh
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Correspondence to E Van Valckenborgh.

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The authors declare no conflict of interest.

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Supplementary Information accompanies the paper on the Leukemia website

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Xu, D., Hu, J., Xu, S. et al. Dll1/Notch activation accelerates multiple myeloma disease development by promoting CD138+ MM-cell proliferation. Leukemia 26, 1402–1405 (2012). https://doi.org/10.1038/leu.2011.332

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