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Array-based DNA methylation analysis in classical Hodgkin lymphoma reveals new insights into the mechanisms underlying silencing of B cell-specific genes

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Acknowledgements

This study has been supported by the Deutsche Krebshilfe through the project numbers 107748 to RS, 107736 and 108687 to RK, and the network project ‘Molecular Mechanisms in Malignant Lymphomas’ subproject M2 (70-3173-Tr3 to RS and JIM-S), the Ministerio de Ciencia e Innovación (SAF2009-08663 to JIM-S), the Wilhelm Sander Stiftung (2005.168.2 to RS and RK) and the Kinderkrebsinitiative Buchholz/Holm-Seppensen (pyrosequencing infrastructure to RS). JIM-S is a Ramon y Cajal researcher of the Ministerio de Ciencia e Innovación. MG is supported by a FEBS Long-Term Fellowship and Support for International Mobility of Scientists fellowships of the Polish Ministry of Science and Higher Education.

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Author notes

  1. J I Martín-Subero and R Siebert: These authors share senior authorship.

Authors and Affiliations

  1. Institute of Human Genetics, Christian-Albrechts University Kiel & University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

    O Ammerpohl, A Haake, S Pellissery, M Giefing, J Richter, J I Martín-Subero & R Siebert

  2. Institute of Human Genetics, Polish Academy of Sciences, Poznan, Poland

    M Giefing

  3. Cancer Epigenetics and Biology Program, Bellvitge Institute for Biomedical Research, Barcelona, Spain

    B Balint

  4. Hematopathology Section, Laboratory of Pathology, Hospital Clínic, University of Barcelona, Barcelona, Spain

    M Kulis

  5. Illumina Inc., San Diego, CA, USA

    J Le & M Bibikova

  6. Department of Human and Animal Cell Cultures, DSMZ-German Collection of Microorganisms & Cell Cultures, Braunschweig, Germany

    H G Drexler

  7. Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Essen, Germany

    M Seifert & R Küppers

  8. Department of Pathology, Weill Cornell Medical College, New York, NY, USA

    R Shaknovic

  9. Genomics and Proteomics Core Facility, German Cancer Research Center, Heidelberg, Germany

    B Korn

  10. Department of Anatomic Pathology, Pharmacology and Microbiology, Faculty of Medicine, University of Barcelona, Barcelona, Spain

    J I Martín-Subero

Authors
  1. O Ammerpohl
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  2. A Haake
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  3. S Pellissery
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  4. M Giefing
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  5. J Richter
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  6. B Balint
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  7. M Kulis
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  8. J Le
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  9. M Bibikova
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  10. H G Drexler
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  11. M Seifert
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  12. R Shaknovic
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  13. B Korn
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  14. R Küppers
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  15. J I Martín-Subero
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  16. R Siebert
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Corresponding author

Correspondence to J I Martín-Subero.

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Competing interests

JL and MB are (or were at the time of the research) employees and stockholders of Illumina Inc. OA and JIM-S have received an honorarium for speaking in a meeting organized by Illumina.

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Supplementary Information accompanies the paper on the Leukemia website

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Ammerpohl, O., Haake, A., Pellissery, S. et al. Array-based DNA methylation analysis in classical Hodgkin lymphoma reveals new insights into the mechanisms underlying silencing of B cell-specific genes. Leukemia 26, 185–188 (2012). https://doi.org/10.1038/leu.2011.194

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