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A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases

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References

  1. Perrotti D, Jamieson C, Goldman J, Skorski T . Chronic myeloid leukemia: mechanisms of blastic transformation. J Clin Invest 2010; 120: 2254–2264.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Calabretta B, Perrotti D . The biology of CML blast crisis. Blood 2004; 103: 4010–4022.

    Article  CAS  PubMed  Google Scholar 

  3. Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H et al. Myeloproliferative neoplasms. WHO Classification of Tumours of Haematopoietic and Lympoid Tissues. IARC: Lyon, France, 2008.

    Google Scholar 

  4. Burke BA, Carroll M . BCR-ABL: a multi-faceted promoter of DNA mutation in chronic myelogeneous leukemia. Leukemia 2010; 24: 1105–1112.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Zhang S . The role of aberrant transcription factor in the progression of chronic myeloid leukemia. Leuk Lymphoma 2008; 49: 1463–1469.

    Article  PubMed  Google Scholar 

  6. Iacobucci I, Storlazzi CT, Cilloni D, Lonetti A, Ottaviani E, Soverini S et al. Identification and molecular characterization of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukemia patients: on behalf of Gruppo Italiano Malattie Ematologiche dell'Adulto Acute Leukemia Working Party (GIMEMA AL WP). Blood 2009; 114: 2159–2167.

    Article  CAS  PubMed  Google Scholar 

  7. Abdel-Wahab O, Kilpivaara O, Patel J, Busque L, Levine RL . The most commonly reported variant in ASXL1 (c.1934dupG; p.Gly646TrpfsX12) is not a somatic alteration. Leukemia 2010; 24: 1656–1657.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Miething C, Grundler R, Mugler C, Brero S, Hoepfl J, Geigl J et al. Retroviral insertional mutagenesis identifies RUNX genes involved in chronic myeloid leukemia disease persistence under imatinib treatment. Proc Natl Acad Sci USA 2007; 104: 4594–4599.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to V Grossmann.

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CH, S Schnittger, WK, and TH have equity ownership of MLL Munich Leukemia Laboratory. VG, AK, MZ, CE, S Schindela, and SW are employed by MLL Munich Leukemia Laboratory. MCM and AH declare no conflict of interest.

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Grossmann, V., Kohlmann, A., Zenger, M. et al. A deep-sequencing study of chronic myeloid leukemia patients in blast crisis (BC-CML) detects mutations in 76.9% of cases. Leukemia 25, 557–560 (2011). https://doi.org/10.1038/leu.2010.298

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