References
Liang Y, Van Zant G, Szilvassy SJ . Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. Blood 2005; 106: 1479–1487.
Rossi DJ, Bryder D, Zahn JM, Ahlenius H, Sonu R, Wagers AJ et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci USA 2005; 102: 9194–9199.
Chambers SM, Shaw CA, Gatza C, Fisk CJ, Donehower LA, Goodell MA . Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol 2007; 5: e201.
Mestas J, Hughes CC . Of mice and not men: differences between mouse and human immunology. J Immunol 2004; 172: 2731–2738.
Schmidt M, Bies J, Tamura T, Ozato K, Wolff L . The interferon regulatory factor ICSBP/IRF-8 in combination with PU.1 up-regulates expression of tumor suppressor p15(Ink4b) in murine myeloid cells. Blood 2004; 103: 4142–4149.
Holtschke T, Lohler J, Kanno Y, Fehr T, Giese N, Rosenbauer F et al. Immunodeficiency and chronic myelogenous leukemia-like syndrome in mice with a targeted mutation of the ICSBP gene. Cell 1996; 87: 307–317.
Schwieger M, Lohler J, Friel J, Scheller M, Horak I, Stocking C . AML1-ETO inhibits maturation of multiple lymphohematopoietic lineages and induces myeloblast transformation in synergy with ICSBP deficiency. J Exp Med 2002; 196: 1227–1240.
Schmidt M, Hochhaus A, Nitsche A, Hehlmann R, Neubauer A . Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-alpha. Blood 2001; 97: 3648–3650.
Acknowledgements
This research was supported by the following NIH Grants: AG06781, CA92405, CA114563, CA114563, CA018029, HL66947, CA018029 and DK56465. DLS oversaw the design, analyses and writing of the paper. YEC, ELP and MRC performed most of the experiments. NES, FRA, JPR and SH helped with the design, analyses and interpretation of the studies as well as actively contributed to the writing of the paper. MY, EBL and BLW helped obtain the samples for the studies and actively contributed to the writing of the paper.
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Supplementary Information accompanies the paper on the Leukemia website (http://www.nature.com/leu)
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Stirewalt, D., Choi, Y., Sharpless, N. et al. Decreased IRF8 expression found in aging hematopoietic progenitor/stem cells. Leukemia 23, 391–393 (2009). https://doi.org/10.1038/leu.2008.176
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DOI: https://doi.org/10.1038/leu.2008.176
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