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Simultaneous occurrence of acute myeloid leukaemia with mutated nucleophosmin (NPM1) in the same family

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References

  1. Falini B, Mecucci C, Tiacci E, Alcalay M, Rosati R, Pasqualucci L et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. N Engl J Med 2005; 352: 254–266.

    Article  CAS  Google Scholar 

  2. Cazzaniga G, Dell’Oro MG, Mecucci C, Giarin E, Masetti R, Rossi V et al. Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype. Blood 2005; 106: 1419–1422.

    Article  CAS  Google Scholar 

  3. Falini B, Nicoletti I, Martelli MF, Mecucci C . Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features. Blood 2007; 109: 874–885.

    Article  CAS  Google Scholar 

  4. Thiede C, Creutzig E, Reinhardt D, Ehninger G, Creutzig U . Different types of NPM1 mutations in children and adults: evidence for an effect of patient age on the prevalence of the TCTG-tandem duplication in NPM1-exon 12. Leukemia 2007; 21: 366–367.

    Article  CAS  Google Scholar 

  5. Falini B, Martelli MP, Bolli N, Bonasso R, Ghia E, Pallotta MT et al. Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia. Blood 2006; 108: 1999–2005.

    Article  CAS  Google Scholar 

  6. Song WJ, Sullivan MG, Legare RD, Hutchings S, Tan X, Kufrin D et al. Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia. Nat Genet 1999; 23: 166–175.

    Article  CAS  Google Scholar 

  7. Smith ML, Cavenagh JD, Lister TA, Fitzgibbon J . Mutation of CEBPA in familial acute myeloid leukemia. N Engl J Med 2004; 351: 2403–2407.

    Article  CAS  Google Scholar 

  8. Yamamoto G, Nannya Y, Kato M, Sanada M, Levine RL, Kawamata N et al. Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays. Am J Hum Genet 2007; 81: 114–126.

    Article  CAS  Google Scholar 

  9. Simon-Sanchez J, Scholz S, Fung HC, Matarin M, Hernandez D, Gibbs JR et al. Genome-wide SNP assay reveals structural genomic variation, extended homozygosity and cell-line induced alterations in normal individuals. Hum Mol Genet 2007; 16: 1–14.

    Article  CAS  Google Scholar 

  10. Liso A, Bogliolo A, Freschi V, Martelli MP, Pileri SA, Santodirocco M et al. In human genome, generation of a nuclear export signal through duplication appears unique to nucleophosmin (NPM1) mutations and is restricted to AML. Leukemia 2008; 22: 1285–1289.

    Article  CAS  Google Scholar 

  11. Pasqualucci L, Li S, Meloni G, Schnittger S, Gattenlohner S, Liso A et al. NPM1-mutated acute myeloid leukaemia occurring in JAK2-V617F+ primary myelofibrosis: de-novo origin? Leukemia advance online publication, 17 January 2008; doi:10.1038/sj.leu.2405093.

    Article  CAS  Google Scholar 

  12. Falini B, Mecucci C, Saglio G, Lo Coco F, Diverio D, Brown P et al. NPM1 mutations and cytoplasmic nucleophosmin are mutually exclusive of recurrent genetic abnormalities: a comparative analysis of 2562 patients with acute myeloid leukemia. Haematologica 2008; 93: 439–442.

    Article  CAS  Google Scholar 

  13. Falini B, Martelli MP, Mecucci C, Liso A, Bolli N, Bigerna B et al. Cytoplasmic mutated nucleophosmin is stable in primary leukemic cells and in a xenotransplant model of NPMc+ acute myeloid leukemia in SCID mice. Haematologica 2008; 93: 775–779.

    Article  Google Scholar 

  14. Garzon R, Garofalo M, Martelli MP, Briesewitz R, Wang L, Fernandez-Cymering C et al. Distinctive microRNA signature of acute myeloid leukemia bearing cytoplasmic mutated nucleophosmin. Proc Natl Acad Sci USA 2008; 105: 3945–3950.

    Article  CAS  Google Scholar 

  15. Glass DC, Gray CN, Jolley DJ, Gibbons C, Sim MR, Fritschi L et al. Leukemia risk associated with low-level benzene exposure. Epidemiology 2003; 14: 569–577.

    Article  Google Scholar 

  16. Chou WC, Tang JL, Wu SJ, Tsay W, Yao M, Huang SY et al. Clinical implications of minimal residual disease monitoring by quantitative polymerase chain reaction in acute myeloid leukemia patients bearing nucleophosmin (NPM1) mutations. Leukemia 2007; 21: 998–1004.

    Article  CAS  Google Scholar 

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Acknowledgements

Supported by the Associazione Italiana per la Ricerca sul Cancro (AIRC), MIUR PRIN and Fondazione Cariplo (to GC and AB). LLN was supported by IBISCUS. This work was supported by MIUR (Ministero Università e Ricerca) through a FIRB grant RBLA03ER38 and funds to Interdisciplinary Center for Biomolecular Studies and Industrial Applications (CISI) and Department of Biomedical Sciences and Technologies, University of Milan, Italy. We thank Dr GA Boyd for editorial assistance. B Falini has applied for a patent on the clinical use of NPM mutants.

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Correspondence to B Falini.

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Supplementary Information accompanies the paper on the Leukemia website (http://www.nature.com/leu)

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Cazzaniga, G., Lo Nigro, L., Cifola, I. et al. Simultaneous occurrence of acute myeloid leukaemia with mutated nucleophosmin (NPM1) in the same family. Leukemia 23, 199–203 (2009). https://doi.org/10.1038/leu.2008.170

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