Skip to main content

Advertisement

SpringerLink
Log in

The most frequent t(14;19)(q32;q13)-positive B-cell malignancy corresponds to an aggressive subgroup of atypical chronic lymphocytic leukemia

  • Letter to the Editor
  • Published:
Leukemia Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1

References

  1. McKeithan TW, Rowley JD, Shows TB, Diaz MO . Cloning of the chromosome translocation breakpoint junction of the t(14;19) in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 1987; 84: 9257–9260.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Soma LA, Gollin SM, Remstein ED, Ketterling RP, Flynn HC, Rajasenan KK et al. Splenic small B-cell lymphoma with IGH/BCL3 translocation. Hum Pathol 2006; 37: 218–230.

    Article  CAS  PubMed  Google Scholar 

  3. Huh YO, Abruzzo LV, Rassidakis GZ, Parry-Jones N, Schlette E, Brito-Bapabulle V et al. The t(14;19)(q32;q13)-positive small B-cell leukaemia: a clinicopathologic and cytogenetic study of seven cases. Br J Haematol 2007; 136: 220–228.

    Article  CAS  PubMed  Google Scholar 

  4. Dohner H, Stilgenbauer S, Benner A, Leupolt E, Krober A, Bullinger L et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910–1916.

    Article  CAS  PubMed  Google Scholar 

  5. Martin-Subero JI, Ibbotson R, Klapper W, Michaux L, Callet-Bauchu E, Berger F et al. A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation. Leukemia 2007; 21: 1532–1544.

    Article  CAS  PubMed  Google Scholar 

  6. Murray F, Darzentas N, Hadzidimitriou A, Tobin G, Boudjogra M, Scielzo C et al. Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis. Blood 2008; 111: 1524–1533.

    Article  CAS  PubMed  Google Scholar 

  7. Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK . Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94: 1848–1854.

    CAS  PubMed  Google Scholar 

  8. Mayr C, Speicher MR, Kofler DM, Buhmann R, Strehl J, Busch R et al. Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia. Blood 2006; 107: 742–751.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

We gratefully acknowledge M Busson, J Ong and L Merlin for excellent technical assistance, F Gaillard for histopathological review, C Lesty for statistical analysis, and the other participants of each institute: K Maloum, S Choquet, S Daliphard, B Chetaille, E Bergoin, M Lessard, F Dupré, J-L Lai, D Mühlematter, P-Y Lovey, F Picard.

Author information

Authors and Affiliations

  1. Service d’Hématologie Biologique, Assistance Publique-Hôpitaux de Paris Pitié-Salpêtrière, Paris, France

    E Chapiro, H Merle-Béral, F Davi & F Nguyen-Khac

  2. UPMC, Univ Paris 06, Paris, France

    E Chapiro, H Merle-Béral, F Davi & F Nguyen-Khac

  3. INSERM EMI0210, Necker-Enfants Malades, Paris, France

    E Chapiro, I Radford-Weiss, O A Bernard, R Berger & F Nguyen-Khac

  4. Laboratoire de Cytogénétique, CHU Necker-Enfants Malades, Paris, France

    I Radford-Weiss

  5. Laboratoire de Génétique Oncologique, Centre H Becquerel, Rouen, France

    C Bastard

  6. Service de Génétique, CHU Reims, Reims, France

    I Luquet

  7. Laboratoire d’Hématologie Cellulaire et Moléculaire, CHU Grenoble, Grenoble, France

    C Lefebvre & D Leroux

  8. Service d’Hématologie Biologique, CH Lyon Sud, Lyon, France

    E Callet-Bauchu & P Felman

  9. Oncohématologie, CHU Nantes, Nantes, France

    P Talmant

  10. Institut Paoli-Calmettes, Marseille, France

    M-J Mozziconacci

  11. Laboratoire de Cytogénétique, CHU Dijon, Dijon, France

    F Mugneret

  12. Laboratoire d’Hématologie, CHRU Strasbourg, Strasbourg, France

    S Struski

  13. Laboratoire d’oncohématologie, Hôpital Pasteur, Nice, France

    S Raynaud

  14. Laboratoire de Génétique Médicale, CHRU Lille, Lille, France

    J Andrieux

  15. Service de Génétique, CHU Tours, Tours, France

    C Barin

  16. Cytogénétique du Cancer, CHUV Lausanne, Lausanne, Suisse,

    M Jotterand

  17. Laboratoire Pasteur-Cerba, Cergy Pontoise, France

    H Mossafa

  18. Service d’Hématologie, CHU Hôtel-Dieu, Paris, France

    S Ramond

  19. Laboratoire de Cytogénétique, CH Versailles, Versailles, France

    C Terré

  20. Laboratoire de Cytogénétique, CHU Bordeaux, Bordeaux, France

    E Lippert

  21. Service d’Anatomopathologie, CH Lyon Sud, Lyon, France

    F Berger

Authors
  1. E Chapiro
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I Radford-Weiss
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C Bastard
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I Luquet
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. C Lefebvre
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. E Callet-Bauchu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. D Leroux
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. P Talmant
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. M-J Mozziconacci
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. F Mugneret
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. S Struski
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. S Raynaud
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. J Andrieux
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. C Barin
    View author publications

    You can also search for this author in PubMed Google Scholar

  15. M Jotterand
    View author publications

    You can also search for this author in PubMed Google Scholar

  16. H Mossafa
    View author publications

    You can also search for this author in PubMed Google Scholar

  17. S Ramond
    View author publications

    You can also search for this author in PubMed Google Scholar

  18. C Terré
    View author publications

    You can also search for this author in PubMed Google Scholar

  19. E Lippert
    View author publications

    You can also search for this author in PubMed Google Scholar

  20. F Berger
    View author publications

    You can also search for this author in PubMed Google Scholar

  21. P Felman
    View author publications

    You can also search for this author in PubMed Google Scholar

  22. H Merle-Béral
    View author publications

    You can also search for this author in PubMed Google Scholar

  23. O A Bernard
    View author publications

    You can also search for this author in PubMed Google Scholar

  24. F Davi
    View author publications

    You can also search for this author in PubMed Google Scholar

  25. R Berger
    View author publications

    You can also search for this author in PubMed Google Scholar

  26. F Nguyen-Khac
    View author publications

    You can also search for this author in PubMed Google Scholar

Consortia

on behalf of the Groupe Francophone de Cytogénétique Hématologique (GFCH)

Corresponding author

Correspondence to F Nguyen-Khac.

Additional information

Supplementary Information accompanies the paper on the Leukemia website (http://www.nature.com/leu)

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Cite this article

Chapiro, E., Radford-Weiss, I., Bastard, C. et al. The most frequent t(14;19)(q32;q13)-positive B-cell malignancy corresponds to an aggressive subgroup of atypical chronic lymphocytic leukemia. Leukemia 22, 2123–2127 (2008). https://doi.org/10.1038/leu.2008.102

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/leu.2008.102

  • Springer Nature Limited

This article is cited by

Search

Navigation