Abstract
Compared to other laboratory animals, little is known about the use of anesthetics in birds, potentially resulting in the use of improper dosing regimens. The authors compared two commonly used ketamine combinations with isoflurane and concluded that the injectable doses were ineffective for induction of surgical anesthesia in chickens.
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Johnson, P.A., Brooks, C., Wang, S.Y. & Chen, C.C. Plasma concentrations of immunoreactive inhibin and gonadotropins following removal of ovarian follicles in the domestic hen. Biol. Reprod. 49(5), 1026–1031 (1993).
Burke, W.H. & Edwards, H.M. Jr. Effect of early castration on body weight, muscle growth, and bone characteristics of male Nicholas strain turkeys. Poult. Sci. 73(3), 457–463 (1994).
Cason, J.A., Fletcher, D.L. & Burke, W.H. Influence of caponization on skin pigmentation of male broilers. Poult. Sci. 66(3), 433–438 (1987).
Olson, L.M. et al. The Hen as an Animal Model for Human Ovarian Epithelial Adenocarcinoma. Presented at XIth Ovarian Workshop: Ovarian Cell Growth, Apoptosis and Cancer, Serono Symposium, July 1996, London, Ontario, Canada.
Fedde, M.R. Drugs used for avian anesthesia: a review. Poult. Sci. 57(5), 1376–1399, 1978.
Christensen, J., Fosse, R.T., Halvorsen, O.J. & Morild, I. Comparison of various anesthetic regimens in the domestic fowl. Am. J. Vet. Res. 48(11), 1649–1657 (1987).
Olsen, G.H. & Orosz, S.E. Manual of Avian Medicine (Mosby, Inc., St. Louis, 2000).
Sinn, L.C. in Avian Medicine: Principles and Application (eds. Ritchie, R.W., Harrison, G.J. & Harrison, L.R.) Ch. 39 (Wingers Publishing Inc., Lake Worth, FL, 1994).
Samour, J.H., Jones, D.M., Knight, J.A. & Howlett, J.C. Comparative studies of the use of some injectable anaesthetic agents in birds. Vet. Rec. 115(1), 6–11 (1984).
Olkowski, A.A. & Classen, H.L. Safety of isoflurane anaesthesia in high risk avian patients. Vet. Rec. 143(3), 82–83 (1998).
Wixson, S.K., White, W.J., Hughes, H.C. Jr, Lang, C.M. & Marshall, W.K. A comparison of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam anesthesia in adult male rats. Lab. Anim. Sci. 37(6), 726–730 (1987).
Wixson, S.K., White, W.J., Hughes, H.C. Jr, Marshall, W.K. & Lang, C.M. The effect of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on noxious stimulus perception in adult male rats. Lab. Anim. Sci. 37(6), 731–735 (1987).
Plumb, D.C. Veterinary Drug Handbook 3rd edn 365 (Iowa State University Press, Ames, IA, 1999).
Harrison, G.J. Pre-anesthetic fasting recommended. J. Assoc. Avian Vet. 5, 126 (1991).
McGrath, C.J., Lee, J.C. & Campbell, V.L. Dose-response anesthetic effects of ketamine in the chicken. Am. J. Vet. Res. 45(3), 531–534 (1984).
Degernes, L.A., Kreeger, T.J., Mandsager, R. & Redig, P.T. Ketamine/xylazine anesthesia in red-tailed hawks with antagonism by yohimbine. J. Wildl. Dis. 24(2), 322–326 (1988).
Komulainen, A. & Olsen, M.E. Antagonism of ketamine-xylazine anesthesia in rats by administration of yohimbine, tolazoline, or 4-aminopyridine. Am. J. Vet. Res. 52(4), 585–588 (1991).
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Varner, J., Clifton, K., BS, S. et al. Lack of Efficacy of Injectable Ketamine with Xylazine or Diazepam for Anesthesia in Chickens. Lab Anim 33, 36–39 (2004). https://doi.org/10.1038/laban0504-36
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DOI: https://doi.org/10.1038/laban0504-36
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