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Use of the i-STAT portable clinical analyzer in mice

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Lab Animal

Abstract

The use of portable chemistry analyzers is an attractive option for obtaining clinical pathology panels in mice, because these analyzers require only small volumes of whole blood. However, in studies with other animals, portable analyzers do not always agree with results obtained using standard laboratory equipment. The authors evaluated the use of the i-STAT handheld portable clinical analyzer compared to the use of standard nonportable laboratory instruments in mice. As shown with other species, the i-STAT results did not always agree with standard laboratory instruments; however, the i-STAT does show reliability for certain chemistry assays.

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Figure 1: Bland-Altman plot comparing differences in hemoglobin values between the i-STAT analyzer and the Abbott Cell-Dyn 3700 CS hematology analyzer.
Figure 2: Scatterplot of mean hemoglobin values of paired samples versus the differences in values between the two methods (i-STAT − CellDyne).

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Acknowledgements

The authors thank Helen Jackson and the staff of the Section of Veterinary Laboratory Medicine for technical assistance, Lianchun Xiao of the Department of Biostatistics and Applied Mathematics for assistance with statistical analyses, and Dr. Kenneth N. Gray of the Department of Veterinary Medicine and Surgery at the University of Texas M.D. Anderson Cancer Center for providing financial support for this study.

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Authors and Affiliations

  1. Department of Veterinary Medicine and Surgery, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd., Houston, 77030, TX

    Peggy Tinkey DVM, Thomas Lembo DVM, Suzanne Craig DVM, Cheri West DVM & Carolyn Van Pelt DVM, PhD

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  1. Peggy Tinkey DVM
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  2. Thomas Lembo DVM
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  3. Suzanne Craig DVM
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  4. Cheri West DVM
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  5. Carolyn Van Pelt DVM, PhD
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Correspondence to Peggy Tinkey DVM.

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The authors declare no competing financial interests.

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Tinkey, P., Lembo, T., Craig, S. et al. Use of the i-STAT portable clinical analyzer in mice. Lab Anim 35, 45–50 (2006). https://doi.org/10.1038/laban0206-45

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  • DOI: https://doi.org/10.1038/laban0206-45

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