Abstract
Antigenic modulation of major histocompatibility and tumour associated antigens was observed in neoplastic cells obtained from patients with pleural and abdominal effusions of breast and ovary carcinomas following a single intracavitary dose of 18 x 10(6) U recombinant IFN-alpha. This regimen resulted in antigenic modulation in seven out of 11 tested cases, suggesting a potential, although limited, responsiveness of at least a fraction of breast and ovary carcinoma cells to in situ biomodification with IFN-alpha.
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Giacomini, P., Mottolese, M., Fraioli, R. et al. Antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-α. Br J Cancer 66, 342–344 (1992). https://doi.org/10.1038/bjc.1992.267
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DOI: https://doi.org/10.1038/bjc.1992.267
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