Abstract
Tumour-cell growth in lung nodules after i.v. transfer to sublethally irradiated mice has been followed after adoptive transfer of different populations of lymphoid cells. Spleen cells deliberately immunized in vitro and in vivo against stimulator cells bearing embryo-associated antigens and which are cytostatic in vitro for targets bearing such antigens, can diminish the number of lung nodules found after i.v. transfer. In contrast, cytotoxic (in vitro) spleen cells, while capable of diminishing local (s.c.) growth of tumour cells, cannot control systemic tumour growth. Within a given solid tumour mass, the subpopulations resistant to cytostatic effector cells in vitro are the ones most likely to produce lung colonies after adoptive transfer in vivo, though they show no more local (s.c.) growth than to cytostatic-sensitive cells in vivo.
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Gorczynski, R., MacRae, S. Tumour-cell susceptibility to cytotoxic or cytostatic effector cells in vitro and the regulation of tumour-cell growth in vivo. Br J Cancer 43, 32–43 (1981). https://doi.org/10.1038/bjc.1981.5
Issue Date:
DOI: https://doi.org/10.1038/bjc.1981.5
- Springer Nature Limited
This article is cited by
-
Character of changes in cytostatic and cytotoxic functions of mouse splenocytes after immobilization stress
Bulletin of Experimental Biology and Medicine (1985)