Abstract
A series of xenografts of human breast carcinomas has been established and serially transplanted in immune-suppressed mice. Certain structural and functional features of the original human tumours, including carcinoembryonic antigen and epithelial membrane antigen, continue to be expressed by the resulting xenografts. Stromal responses such as elastosis and oestrogen-receptor activity were lost by the xenografts. No metastases were detected in tumour-bearing mice. This study suggests that xenografts may have some value in experimental pathology as one type of model of human breast carcinoma.
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Bailey, M., Ormerod, M., Imrie, S. et al. Comparative functional histopathology of human breast carcinoma xenografts. Br J Cancer 43, 125–134 (1981). https://doi.org/10.1038/bjc.1981.20
Issue Date:
DOI: https://doi.org/10.1038/bjc.1981.20
- Springer Nature Limited
This article is cited by
-
Human tumor xenografts as model for drug testing
CANCER AND METASTASIS REVIEW (1988)
-
Endocrine therapy of human breast cancer grown in nude mice
Breast Cancer Research and Treatment (1987)
-
The potential of the nude mouse xenograft model for the study of head and neck cancer
Archives of Oto-Rhino-Laryngology (1984)