Abstract
Newborn mice have a lower spontaneous resistance to the growth of a syngeneic plasmacytoma (MOPC-460) as compared to adult mice. The transfer of different leucocyte populations from non-immunized adult donors to newborn mice influence in a dual way the resistance to MOPC-460 growth, depending on the number of cells transferred. The transfer of a low number of neutrophils, thymus or spleen cells enhances the MOPC-460 takes. Higher numbers of neutrophils, thymus or bone marrow cells induce an effective protenction. By contrast, macrophages over a dose of 1 X 10(4) constantly produce a reduction of tumour growth.
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Giovarelli, M., Comoglio, P. & Forni, G. Induction of resistance or enhancement to a transplantable murine plasmacytoma by transfer of non-immune leucocytes. Br J Cancer 34, 233–238 (1976). https://doi.org/10.1038/bjc.1976.157
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DOI: https://doi.org/10.1038/bjc.1976.157
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