Abstract
Autopsy records based on 647 primary carcinomata of the breast provided the data to describe a few possible routes of dissemination of cancer of the breast. Calculations were made to test whether the hypothesis of a multistep dissemination of the tumour from the primary site was likely. A multistep dissemination means that the presence of metastases at peripheral sites is influenced by the presence of the tumour in 3 organs, i.e. lungs, liver and bones, very often seeded by the primary cancer.
Several interpretations are discussed, with emphasis on those findings which could be explained in terms of a haematic route of dissemination or in terms of an anatomical proximity.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Rights and permissions
About this article
Cite this article
Viadana, E., Bross, I. & Pickren, J. An Autopsy Study of Some Routes of Dissemination of Cancer of the Breast. Br J Cancer 27, 336–340 (1973). https://doi.org/10.1038/bjc.1973.40
Issue Date:
DOI: https://doi.org/10.1038/bjc.1973.40
- Springer Nature Limited
This article is cited by
-
Model-based inference of metastatic seeding rates in de novo metastatic breast cancer reveals the impact of secondary seeding and molecular subtype
Scientific Reports (2022)
-
Spontaneous dormancy of metastatic breast cancer cells in an all human liver microphysiologic system
British Journal of Cancer (2014)
-
Role of the host stroma in cancer and its therapeutic significance
Cancer and Metastasis Reviews (2013)
-
Partial Mesenchymal to Epithelial Reverting Transition in Breast and Prostate Cancer Metastases
Cancer Microenvironment (2012)
-
Arterial therapies of non-colorectal cancer metastases to the liver (from chemoembolization to radioembolization)
Abdominal Imaging (2011)