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Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases

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Figure 1: Sequence alignments, structures and expression patterns of mouse Dnmt3a and Dnmt3b.
Figure 2: De novo and maintenance methyltransferase activities of Dnmt3α and Dnmt3β.

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Acknowledgements

We thank P. Oh for the ES cell RNA blot. This work was supported by grants from NIH (GM52106) and Bristol Myers-Squibb to E.L. M.O. was a postdoctoral fellow of the Japan Society for the Promotion of Science.

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    1. Department of Medicine, Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA

      Masaki Okano, Shaoping Xie & En Li

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    1. Masaki Okano
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    2. Shaoping Xie
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    3. En Li
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    Correspondence to En Li.

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    Okano, M., Xie, S. & Li, E. Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases. Nat Genet 19, 219–220 (1998). https://doi.org/10.1038/890

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