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DNA Methylation in Early Mammalian Development

  • Chapter
DNA Methylation

Part of the book series: Springer Series in Molecular Biology ((SSMOL))

Abstract

The genomic DNAs of vertebrates and many invertebrates contain 5-methylcytosine (5-meCyt) as the only modified base (Table 10.1). Considerable interest in DNA methylation has been created by increasing evidence that links methylation patterns to patterns of gene expression in differentiation. An inverse correlation between methylation and transcriptional activity has been found for a number of developmentally regulated genes; it will be reviewed elsewhere (see Chapter 8).

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References

  • Banerji J, Olson L, Schaffner W: A lymphocytespecific cellular enhancer is located downstream of the joining region in immunoglobulin heavy chain genes. Cell 1983; 33: 729–740.

    PubMed  CAS  Google Scholar 

  • Bird AP, Taggart MH, Smith BA: Methylated and unmethylated DNA compartments in the sea urchin genome. Cell 1979; 17: 889–901.

    PubMed  CAS  Google Scholar 

  • Bird, AP, Taggart MH: Variable patterns of total DNA and rDNA methylation in animals. Nucleic Acids Res 1980; 8: 1485–1497.

    PubMed  CAS  Google Scholar 

  • Bird A, Taggart M, Macleod D: Loss of rDNA methylation accompanies the onset of ribosomal gene activity in early development of X. laevis. Cell 1981; 26: 381–390.

    PubMed  CAS  Google Scholar 

  • Braude P, Pelham H, Flach G, Lobatto R: Post-transcriptional control in the early mouse embryo. Nature 1979; 282: 102–105.

    PubMed  CAS  Google Scholar 

  • Breindl M, Nath U, Jähner D, Jaenisch R: DNase I sensitivity of endogenous and exogenous proviral genome copies in M-MuLV-induced tumors of Mov-3 mice. Virology 1982; 119: 204–208.

    PubMed  CAS  Google Scholar 

  • Breindl M, Harbers K, Jaenisch R: Retrovirus-induced lethal mutation in collagen I gene of mice is associated with an altered chromatin structure. Cell 1984; in press.

    Google Scholar 

  • Brinster RL, Chen HY, Warren R, Sarthy, A, Palmiter RD: Regulation of metallothionein-thymidine kinase fusion plasmids injected into mouse eggs. Nature 1982; 296: 39–42.

    PubMed  CAS  Google Scholar 

  • Brinster RL, Ritchie KA, Hammer RE, O’Brien RL, Arp B, Storb U: Expression of a microinjected immunoglobin gene in the spleen of transgenic mice. Nature 1983; 306: 332–336.

    PubMed  CAS  Google Scholar 

  • Bryan P, Olah J, Birnstiel M: Major changes in the 51 and 31 chromatin structure of sea urchin histone genes accompany their activation and inactivation in development. 1983;Cell 33: 843–848.

    PubMed  CAS  Google Scholar 

  • Burch JBE, Weintraub H: Temporal order of chromatin structural changes associated with activation of the major chicken vitellogenin gene. Cell 1983; 33: 65–76.

    PubMed  CAS  Google Scholar 

  • Busslinger M, Hurst J, Flavell RA: DNA methylation and the regulation of globin gene expression. Cell 1983; 34: 197–206.

    PubMed  CAS  Google Scholar 

  • Cedar H, Stein R, Gruenbaum Y, Naveh-Manyy T, Sciaky-Gallili N, Razin A: Effect of DNA methylation on gene expression, in Cold Spring Harbor Symposia on Quantitative Biology: Structures of DNA. Cold Spring Harbor Laboratory, Cold Spring Harbor, Cold Spring Harbor Laboratory, 1983, vol 47, pp 605–609.

    Google Scholar 

  • Chapman V, Forrester C, Sanford J, Hastie N, Rossant J: Cell lineage specific undermethylation of mouse repetitive DNA. Nature 1984; 307: 284–286.

    PubMed  CAS  Google Scholar 

  • Christy B, Scangos G: Expression of transferred thymidine kinase genes is controlled by methylation. Proc Nall Acad Sci 1982; 79: 6299–6303.

    CAS  Google Scholar 

  • Chumakov I, Stuhlmann H, Harbers K, Jaenisch R: Cloning of two genetically transmitted Moloney leukemia proviral genomes: correlation between biological activity of the cloned DNA and viral genome activation in the animal. J Virol 1982; 42: 1088–1098.

    PubMed  CAS  Google Scholar 

  • Clough DW, Kunkel LM, Davidson RL: 5-Azacytidine-induced reactivation of a herpes simplex thymidine kinase gene. Science 1982; 216: 70–73.

    PubMed  CAS  Google Scholar 

  • Coffin J: Endogenous viruses, in Weiss R, Teich N, Varmus H, Coffin J (eds): RNA Tumor Viruses. Cold Spring Harbor Laboratory, Cold Spring harbor, New York, 1982; pp 1109–1203.

    Google Scholar 

  • Cohen JC: Methylation of milk-borne and genetically transmitted mouse mammary tumor virus proviral DNA. Cell 1980; 19: 653–662.

    PubMed  CAS  Google Scholar 

  • Conklin KF, Coffin JM, Robinson HL, Groudine M, Eisenman R: Role of methylation in the induced and spontaneous expression of the avian endogenous virus ev-1: DNA structure and gene products. Mol Cell Biol 1982; 2: 638–652.

    PubMed  CAS  Google Scholar 

  • Crépin M, Gros F: Regulation of mouse mammary tumor viral RNA synthesis in embryonal carcinoma cells and in teratocarcinoma derived myoblasts. Biochem Biophys Res Comm 1979; 87: 781–788.

    PubMed  Google Scholar 

  • Dandolo L, Blangy D, Kamen R: Regulation of polyoma virus transcription in murine embryonal carcinoma cells. J Virol 1983; 47: 55–64.

    PubMed  CAS  Google Scholar 

  • D’Auriol L, Yang WK, Tobaly J, Cavalieri F, Périès J, Emanoil-Ravicovitch R: Studies on the restriction of ecotropic murine retrovirus replication in mouse teratocarcinoma cells. J Gen Virol 1981; 55: 117–122.

    PubMed  Google Scholar 

  • Davidson EH: Gene Activity in Early Development, ed 2. New York, San Francisco, London, Academic Press, 1976.

    Google Scholar 

  • Davidson EH, Hough-Evans BR, Britten RJ: Molecular biology of the sea urchin embryo, Science 1982; 217: 17–26.

    PubMed  CAS  Google Scholar 

  • Desrosiers RC: Specifically unmethylated cytidylic-guanylate sites in Herpesvirus saimini DNA in tumor cells. J Virol 1982; 43: 427–435.

    PubMed  CAS  Google Scholar 

  • Doskocil J, orm F: Distribution of 5-methyl-cytosine in pyrimidine sequences of deoxyribonucleic acids. Biochim Biophys Acta 1962; 55: 953–959.

    PubMed  CAS  Google Scholar 

  • Ehrlich M, Gama-Sosa MA, Huang L-H, Midgett RM, Kuo KC, McCune RA, and Gehrke C: Amount and distribution of 5-methylcytosine in human DNA from different types of tissues or cells. Nucleic Acids Res. 1982; 10: 2709–2721.

    PubMed  CAS  Google Scholar 

  • Elgin SCR: DNAase I-hypersensitive sites of chromatin. Cell 1981; 27: 413–415.

    PubMed  CAS  Google Scholar 

  • Fiedler W, Nobis P, Jähner D, Jaenisch R: Differentiation and virus expression in BALB/Mo mice: endogenous Moloney leukemia virus is not activated in hemotopoietic cells. Proc Natl Acad Sci (USA) 1982; 79: 1874–1878.

    CAS  Google Scholar 

  • Flavell RA, Grosveld F, Busslinger M, de Beer E, Kioussis D, Mellor AL, Golden L, Weiss E, Hurst J, Bud H, Bullman H, Simpson E, James R, Santamaria M, Atfield G, Festenstein H: Structure and expression of the human globin genes and murine histocompatability antigen genes, in Cold Spring Harbor Symposia on Quantitative Buiology: Structures of DNA. Cold Spring Harbor Laboratory, Cold Spring Harbor, Cold Spring Harbor Laboratory, 1983,vol 47, pp 1067–1068.

    Google Scholar 

  • Fujimura FK, Deininger PL, Friedmann T, Linney E: Mutation near the polyoma DNA replication origin permits productive infection of F9 embryonal carcinoma cells. Cell 1981; 23: 809–814.

    PubMed  CAS  Google Scholar 

  • Gautsch JW, Wilson MC: Delayed de novo methylation in teratocarcinoma suggests additional tissue-specific mechanisms for controlling gene expression. Nature 1983; 301: 32–37.

    PubMed  CAS  Google Scholar 

  • Gerber-Huber S, May FEB, Westley BR, Felber BK, Hosbach HA, Andres A-C, Ryffel GU: In contrast to the Xenopus genes the estrogen-inducible vitellogenin genes are expressed when totally methylated. Cell 1983; 33: 43–51.

    PubMed  CAS  Google Scholar 

  • Giebelhaus, DH, Heikkila JJ, Schultz GA: Changes in the quantity of histone and actin messenger RNA during the development of preimplantation mouse embryos. Dev. Biol 1983; 98: 148–154.

    PubMed  CAS  Google Scholar 

  • Gillies SD, Morrison SL, Oi VT, Tonegawa S: A tissue-specific transcription enhancer element is located in the major intron of a rearranged immunoglobulin heavy chain gene. Cell 1983; 33: 717–728.

    PubMed  CAS  Google Scholar 

  • Grippo P, Iaccarino M, Parisi E, Scarano E: Methylation of DNA in developing sea urchin embryos. J Mol Biol 1968; 36: 195–208.

    PubMed  CAS  Google Scholar 

  • Groudine M, Eisenman R, Weintraub H: Chromatin structure of endogenous retro-viral genes and activation by an inhibitor of DNA methylaion. Nature 1981; 292: 311–317.

    PubMed  CAS  Google Scholar 

  • Guntaka RV, Rao PY, Mitsialis SA, Katz R: Modification of avian sarcoma proviral DNA sequences in nonpermissive XC cells but not in permissive chicken cells. J Virol 1980; 34: 569–572.

    PubMed  CAS  Google Scholar 

  • Harbers K, Jähner D, Jaenisch R: Microinjection of cloned retroviral genomes into mouse zygotes: integration and expression in the animal. Nature 1981a; 293: 540–542.

    PubMed  CAS  Google Scholar 

  • Harbers K, Schnieke A, Stuhlmann H, Jähner D, Jaenisch R: DNA methylation and gene expression: endogenous retorviral genome becomes infectious after molecular cloning. Proc Natl Acad Sci (USA) 1981b; 78: 7609–7613.

    CAS  Google Scholar 

  • Hardies SC, Axelrod DE, Edgell MH, Hutchison III: Phenotypic variation associated with molecular alterations at a cluster of thymidine kinase genes. Mol Cell Biol 1983; 3: 1163–1171.

    PubMed  CAS  Google Scholar 

  • Harland RM: Inheritance of DNA methylation in microinjected eggs of Xenopus laevis. Proc Natl Acad Sci (USA) 1982; 79: 2323–2327.

    CAS  Google Scholar 

  • Hoffmann JW, Steffen D, Gusella J, Tabin C, Bird S, Cowing D, Weinberg RA: DNA methylation affecting the expression of murine leukemia proviruses. J. Virol 1982; 44: 144–157.

    PubMed  CAS  Google Scholar 

  • Hojman-Montes de Oca F, Dianoux L, Périès J, Emanoil-Ravicovitch R: Intracisternal A particles: RNA expression and DNA methylation in murine teratocarcinoma cell lines. J Virol 1983; 46: 307–310.

    Google Scholar 

  • Holliday R, Pugh JE: DNA modification mechanisms and gene activity during development. Science 1975; 187: 226–232.

    PubMed  CAS  Google Scholar 

  • Humphries EH, Glover C, Weiss RA, Arrand JR: Differences between the endogenous and exogenous DNA sequences of Rous-associated virus-O. Cell 1979; 18: 803–815.

    PubMed  CAS  Google Scholar 

  • Jaenisch R, Fan H, Croker B: Infection of preimplantation mouse embryos and of newborn mice with leukemia virus: tissue distribution of viral DNA and RNA and leukemogenesis in the adult animal. Proc Natl Acad Sci (USA) 1975; 72: 4008–4012.

    CAS  Google Scholar 

  • Jaenisch R: Germ line integration and Mendelian transmission of the exogenous Moloney leukemia virus. Proc Natl Acad Sci (USA) 1976; 73: 1260–1264.

    CAS  Google Scholar 

  • Jaenisch R, Berns A: Tumor virus expression during mammalian embryogenesis, in Sherman M, (ed): Concepts in Embryogenesis. Cambridge, Massachusetts, MIT Press, 1977, pp 267–314.

    Google Scholar 

  • Jaenisch R: Retroviruses and embryogenesis: microinjection of Moloney leukemia virus into midgestation mouse embryos. Cell 1980; 19: 181–188.

    PubMed  CAS  Google Scholar 

  • Jaenisch R, Jähner D, Nobis P, Simon I, Lbhler J, Harbers K, Grotkopp D: Chromosomal position and activation or retroviral genomes inserted into the germ line of mice. Cell 1981; 24: 519–529.

    PubMed  CAS  Google Scholar 

  • Jaenisch R: Endogenous retroviruses. Cell 1983; 32: 5–6

    PubMed  CAS  Google Scholar 

  • Jähner D, Jaenisch R: Integration of Moloney leukaemia virus into the germ line of mice: correlation between site of integration and virus activation. Nature 1980; 287: 456–458.

    PubMed  Google Scholar 

  • Jähner D, Stuhlmann H, Stewart CL, Harbers K, Uhler J, Simon I, Jaenisch R: De novo methylation and expression of retroviral genomes during mouse embryogenesis. Nature 1982; 298: 623–628.

    PubMed  Google Scholar 

  • Johnson MH, Handyside AH, Braude PR: Control mechanisms in early mammalian development, in Johnson MH (ed): Development in Mammals. Amsterdam, New York, Oxford, Elsevier/North-Holland Biomedical Press, 1977, vol 2, pp 67–97.

    Google Scholar 

  • Kappler JW: The 5-methylcytosine content of DNA: tissue specificity. J Cell Physiol 1971; 78: 33–36.

    PubMed  CAS  Google Scholar 

  • Kelly F, Condamine H: Tumor viruses and early mouse embryos. Biochim Biophys Acta 1982; 651: 105–141.

    PubMed  CAS  Google Scholar 

  • Khoury G, Gruss P: Enhancer elements. 1983;Ce1l 33:3113–314.

    Google Scholar 

  • Kintner C, Sugden G: Conservation and progressive methylation of Epstein-Barr viral DNA sequences in transformed cells. J Virol 1981; 38: 305–316.

    PubMed  CAS  Google Scholar 

  • Kratzer PG, Chapman VM, Lambert H, Evans RE, Liskay RM: Differences in the DNA of the inactive X chromosomes of fetal and extraembryonic tissues of mice. Cell 1983; 33: 37–42.

    PubMed  CAS  Google Scholar 

  • Kruczek I, Doerfler W: Expression of the chloramphenicol acetyltransferase gene in mammalian cells under the control of adenovirus type 12 promoters: effect of pro-motor methylation on gene expression. Proc Natl Acad Sci (USA) 1983; 80: 7586–7590.

    CAS  Google Scholar 

  • Kuhlmann I, Doerfler W: Shifts in the extent and patterns of DNA methylation upon explanation and subcultivation of adenovirus type 12-induced hamster tumor cells. Virology 1982; 118: 169–180.

    PubMed  CAS  Google Scholar 

  • Kunnath L, Locker J: Characterization of DNA methylation in the rat. Biochem Biophys Acta 1982; 699: 264–271.

    PubMed  CAS  Google Scholar 

  • Lacy E, Roberts S, Evans EP, Burtenshaw D, Constantini FD: A foreign ß-globin gene in transgenic mice: integration at abnormal chromosomal positions and expression in inappropriate tissues. Cell 1983; 34: 343–358.

    PubMed  CAS  Google Scholar 

  • Lerner RA, Wilson CB, Del Villano BC, McConahey PJ, Dixon FJ: Endogenous oncornaviral gene expression in adult and fetal mice: quantitative, histologic, and physiologic studies of the major viral glycoprotein, gp70. J Exp Med 1976; 143: 151–166.

    PubMed  CAS  Google Scholar 

  • Levine AJ: The nature of he host range restriction of SV40 and Polyoma viruses in embryonal carcinoma cells. Curr Top Microbiol Immunol. 1982; 101: 1–30.

    PubMed  CAS  Google Scholar 

  • Manes C, Menzel P: Demethylation of CpG sites in DNA of early rabbit trophoblast. Nature 1981; 293: 589–590.

    PubMed  CAS  Google Scholar 

  • Martin GR: Teratocarcinomas and mammalian embryogenesis. Science 1980; 209: 768–776.

    PubMed  CAS  Google Scholar 

  • Mather EL, Perry RP: Methylation status and DNase I sensitivity of immunoglobulin genes: changes associated with rearrangement. Proc Natl Acad Sci (USA) 1983; 80: 4689–4693.

    CAS  Google Scholar 

  • McGeady ML, Jhappan C, Ascione R, Vande Woude, GF: In vitro methylation of specific regions of the cloned Moloney sarcoma virus genome inhibits its transforming activity. Mol Cell Biol 1983; 3: 305–314.

    PubMed  CAS  Google Scholar 

  • McKeon C, Ohkubo H, Pastan I, de Crombrugghe B: Unusual methylation pattern of the a2(I) collagen gene. Cell 1982; 29: 203–210.

    PubMed  CAS  Google Scholar 

  • McKnight G, Hammer R, Kuenzel E, Brinster R: Expression of the chicken transfer-rin gene in transgenic mice. Cell 1983; 34: 335–341.

    PubMed  CAS  Google Scholar 

  • Niwa O, Sugahara T: 5-Azacytidine induction of mouse endogenous type C virus and suppression of DNA methylation. Proc Natl Acad Sci (USA) 1981; 78: 6290–6294.

    CAS  Google Scholar 

  • Niwa O, Yokota Y, Ishida H, Sugahara T: Independent mechanisms involved in suppression of the Moloney leukemia virus genome during differentiation of murine teratocarcinoma cells. Cell 1983; 32: 1105–1113.

    PubMed  CAS  Google Scholar 

  • Nobis P, Jaenisch R: Passive immunotherapy prevents expression of endogenous Moloney virus and amplivication of proviral DNA in BALB/Mo mice. Proc Natl Acad Sci (USA) 1980; 77: 3677–3681.

    CAS  Google Scholar 

  • Ostrander M, Vogel S, Silverstein S: Phenotypic switching in cells transformed with the herpes simplex virus thymidine kinase gene. Mol Cell Biol 1982; 2: 708–714.

    PubMed  CAS  Google Scholar 

  • Pages M, Roizes G: Tissue specificity and organization of CpG methylation in calf satellite DNA 1. Nucleic Acids Res 1982; 10: 565–576.

    CAS  Google Scholar 

  • Palmiter RD, Chen HY, Brinster RL: Differential regulation opf metallothionein-thymidine kinase fusion genes in transgenic mice and their offspring. Cell 1982; 29: 701–710.

    PubMed  CAS  Google Scholar 

  • Périès J, Alves-Cardoso E, Canivet M, Debons-Guillemin MC, Lasneret J: Lack of multiplication of ecotropic murine C-type viruses in mouse teratocarcinoma primitive cells: brief communication. J Natl Cancer Inst. 1977; 59: 463–465.

    Google Scholar 

  • Pikb L, Clegg KB: Quantitative changes in total RNA, total poly(A), and ribosomes in early mouse embryos. Dey Biol 1982; 89: 362–378.

    Google Scholar 

  • Pollock JM Jr, Swihart M, Taylor JH: Methylation of DNA in early development: 5-methyl cytosine content of DNA in sea urchin sperm and embryos. Nucleic Acids Res 1978; 5: 4855–4863.

    PubMed  CAS  Google Scholar 

  • Pollock Y, Stein R, Razin A, Cedar H: Methylation of foreign DNA sequences in eukaryotic cells. Proc Natl Acad Sci (USA) 1980; 77: 6463–6467.

    Google Scholar 

  • Rae PMM, Steele RE: Absence of cytosine methylation at C-C-G-G and G-C-G-C sites in the rDNA coding regions and intervening sequences of Drosophila and the rDNA of other higher insects. Nucleic Acids Res 1979; 6: 2987–2995.

    PubMed  CAS  Google Scholar 

  • Razin A, Riggs AD: DNA methylation and gene function. 1980; 210: 604–610.

    CAS  Google Scholar 

  • Riggs AD: X inactivation, differentiation, and DNA methylation. Cytogenet Cell Genet 1975; 14: 9–25

    PubMed  CAS  Google Scholar 

  • Santi DV, Garrett CE, Barr PJ: On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs. Cell 1983; 33: 9–10.

    PubMed  CAS  Google Scholar 

  • Sawicki JA, Magnuson T, Epstein CJ: Evidence for expression of the paternal genome in the two-cell mouse embryo. Nature 1981; 294: 450–451.

    PubMed  CAS  Google Scholar 

  • Schibler U, Hagenbüchle O, Wellauer PK, Pittet AC: Two promoters of different strengths control the transcription of the mouse alpha-amylase gene Amy-1a in the parotid gland and the liver. Cell 1983; 33: 501–508.

    PubMed  CAS  Google Scholar 

  • Schnieke A, Stuhlmann H, Harbers K, Chumakov I, Jaenisch R: Endogenous Moloney leukemia virus in nonviremic Mov substrains of mice carries defects in the pro-viral genome. J Virol 1983; 45: 505–513.

    PubMed  CAS  Google Scholar 

  • Sherman MI: Developmental biochemistry of preimplantation mammalian embryos. Ann Rev Biochem 1979; 48: 443–470.

    PubMed  CAS  Google Scholar 

  • Shmookler Reis RJ, Goldstein S: Variability of DNA methylation patterns during serial passage of human diploid fibroblasts. Proc Natl Acad Sci (USA) 1982; 79: 3949–3953.

    CAS  Google Scholar 

  • Simon D, Grunert F, v Acken U, Doring HP, Kröger H: DNA-methylase from regenerating rat liver: purification and characterization. Nucleic Acids Res. 1978; 5: 2153–2167.

    PubMed  CAS  Google Scholar 

  • Simon D, Stuhlmann H, Jähner D, Wagner H, Werner E, Jaenisch R: Retrovirus genomes methylated by mammalian but not bacterial methylase are non-infectious. Nature 1983; 304: 275–277.

    PubMed  CAS  Google Scholar 

  • Singer J, Roberts-Ems J, Luthardt FW, Riggs AO: Methylation of DNA in mouse early embryos, teratocarcinoma cells and adult tissues of mouse and rabbit. Nucleic Acids Res 1979; 7: 2369–2385.

    PubMed  CAS  Google Scholar 

  • Speers WC, Gautsch JW, Dixon FJ: Silent infection of murine embryonal carcinoma cells by Moloney murine leukemia virus. Virology 1980; 105: 241–244.

    PubMed  CAS  Google Scholar 

  • Stein R, Gruenbaum Y, Pollack Y, Razin A, Cedar H: Clonal inheritance of the pattern of DNA methylation in mouse cells. Proc Natl Acad Sci (USA) 1982a; 79: 6165.

    Google Scholar 

  • Stein R, Razin A, Cedar H: In vitro methylation of the hamster adenine phosphoribosyltransferase gene inhibits its expression in mouse L cells. Proc Natl Acad Sci. (USA) 1982b; 79: 3418–3422.

    CAS  Google Scholar 

  • Stewart C, Harbers K, Jähner D, Jaenisch R: X-chromosome linked transmission and expression of retroviral genomes microinjected into mouse zygotes. Science 1983a; 22: 760–762.

    Google Scholar 

  • Stewart C, Jähner D, Stuhlmann H, Jaenisch R: Retroviruses as probes for studying gene epxression in mouse embryogenesis, in Conferences on Cell Proliferation: Teratocarcinoma Stem Cells. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, vol 10: (1983b) 379–385.

    Google Scholar 

  • Stewart CL, Stuhlmann H, Jähner D, Jaenisch R: De novo methylation, expression, and infectivity of retroviral genomes introduced into embryonal carcinoma cells. Proc Natl Acad Sci (USA) 1982; 79: 4098–4102.

    CAS  Google Scholar 

  • Strand M, August T, Jaenisch R: Oncornavirus gene expression during embryonal development of the mouse. Virology 1977; 76: 886–890.

    PubMed  CAS  Google Scholar 

  • Stuhlmann H, Jähner D, Jaenisch R: Infectivity and methylation of retroviral genomes is correlated with expression in the animal. Cell 1981; 26: 221–232.

    PubMed  CAS  Google Scholar 

  • Sturm KS, Taylor JH: Distribution of 5-methyl-cytosine in the DNA of somatic and germline cells from bovine tissues. Nucleic Acids Res 1981; 9: 4537–4546.

    PubMed  CAS  Google Scholar 

  • Teich NM, Weiss RA, Martin GR, Lowy DR: Virus infection of murine teratocar-cinoma stem cell lines. Cell 1977; 12: 973–982.

    PubMed  CAS  Google Scholar 

  • van der Ploeg LHT, Flavell RA: DNA methylation in the human A3-globin locus in erythroid and nonerythroid tissues. Cell 1980; 19: 947–958.

    PubMed  Google Scholar 

  • van der Putten H, Quint W, Verma IM, Berns A: Moloney murine leukemia virus-induced tumors: recombinant proviruses in active chromatin regions. Nucleic Acids Res 1982; 10: 577–592.

    PubMed  Google Scholar 

  • Vanyushin BF, Tkacheva SG, Belozersky AN: Rare bases in animal DNA. Nature 1970; 225: 948–949.

    PubMed  CAS  Google Scholar 

  • Vanyushin BF, Mazin AL, Vasilyev VK, Belozersky AN: The content of 5-methylcytosine in animal DNA: the species and tissue specificity. Biochim Biophys Acta 1973; 299: 397–403.

    PubMed  CAS  Google Scholar 

  • Vardimon L, Kressmann A, Cedar H, Maechler M, Doerfler W: Expression of a cloned adenovirus gene is inhibited by in vitro methylation. Proc Natl Acad Sci (USA) 1982; 79: 1073–1077.

    CAS  Google Scholar 

  • Waalwijk C, Flavell RA: DNA methylation at a CCGG sequence in the large intron of the rabbit (3-globin gene: tissue-specific variations. Nucleic Acids Res 1978; 5: 4631–4641.

    PubMed  CAS  Google Scholar 

  • Wigler M, Levy D, Perucho M: The somatic replication of DNA methylation. Cell 1981; 24: 33–40.

    PubMed  CAS  Google Scholar 

  • Wigler MH: The inheritance of methylation patterns in vertebrates. Cell 1981; 24: 285–286.

    PubMed  CAS  Google Scholar 

  • Wilson VL, Jones P: DNA methylation decreases in aging but not in immortal cells. Science 1983; 220: 1055–1057.

    PubMed  CAS  Google Scholar 

  • Wyatt GR: Recognition and estimation of 5-methyl-cytosine in nucleic acids. Biochem J 1951; 48: 581–590.

    PubMed  CAS  Google Scholar 

  • Yotsuyanagi Y, Szöllösi D: Early mouse embryo intracisternal particle: fourth type of retrovirus-like particle associated with the mouse. J Natl Cancer Inst 1981; 67: 677–685.

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg, Martinistrasse 52, 2000, Hamburg 20, Federal Republic of Germany

    Detlev Jähner & Rudolf Jaenisch

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  1. Detlev Jähner
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  2. Rudolf Jaenisch
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Editors and Affiliations

  1. Department of Cellular Biology, The Hebrew University Hadassah Medical School, 91-010, Jerusalem, Israel

    Aharon Razin (Chairman) (Chairman)

  2. Department of Cellular Biochemistry, The Hebrew University Hadassah Medical School, 91-010, Jerusalem, Israel

    Howard Cedar

  3. Beckman Research Institute of the City of Hope, 91010, Duarte, California, USA

    Arthur D. Riggs

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Jähner, D., Jaenisch, R. (1984). DNA Methylation in Early Mammalian Development. In: Razin, A., Cedar, H., Riggs, A.D. (eds) DNA Methylation. Springer Series in Molecular Biology. Springer, New York, NY. https://doi.org/10.1007/978-1-4613-8519-6_10

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  • DOI: https://doi.org/10.1007/978-1-4613-8519-6_10

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