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Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls

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Abstract

A genetic association between NOTCH4 and schizophrenia has previously been proposed1. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observaton. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.

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Acknowledgements

We thank the patients and families for participation and Y.-M. Lim for technical assistance. This study was funded by a research grant from Bristol-Myers Squibb, Millennium Pharmaceuticals and Affymetrix (E.S.L.); the Medical Research Council (UK), the Wellcome Trust, and the Jansen Research Foundation (M.J.O., M.C.O. and G.K.); the German Israeli Foundation for Scientific Research (D.B.W. and B.L.); and Deutsche Forschungsgemeinschaft (SFB400) (W.M. and D.B.W.).

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Authors and Affiliations

  1. Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA

    Pamela Sklar

  2. Harvard Medical School, Boston, 02115, Massachusetts, USA

    Pamela Sklar

  3. Whitehead Institute/MIT Center for Genome Research, One Kendall Square, Building 300, Cambridge, 02139, Massachusetts, USA

    Pamela Sklar, Mark Daly, Stephen Schaffner & Eric S. Lander

  4. Department of Psychiatry, Molecular Genetics Laboratory, University of Bonn, Bonn, D-53111, Germany

    Sibylle G. Schwab & Dieter B. Wildenauer

  5. Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, CF4 4XN, UK

    Nigel M. Williams, Nadine Norton, Hywel Williams, Stan Zammit, Alastair G. Cardno, Sue Jones, Geraldine McCarthy, George Kirov, Michael C. O'Donovan & Michael J. Owen

  6. Department of Psychiatry, University of Bonn, Bonn, D-53105, Germany

    Wolfgang Maier

  7. Mental State Hospital, Haar, D-85529, Germany

    Margot Albus

  8. Department of Psychiatry, University Medical School of Pecs, Pecs, Hungary, H-7623

    Matyas Trixler

  9. Department of Psychiatry, University of Regensburg, Regensburg, D-93042, Germany

    Peter Eichhammer

  10. Department of Psychiatry, Hadassah-Hebrew University Medical Center, Jerusalem, 91120, Israel

    Bernard Lerer

  11. Graylands Hospital/University of Western Australia, Centre for Clinical Research in Neuropsychiatry, Mt Claremont, 6010, WA, Australia

    Joachim Hallmayer

  12. Department of Psychiatry, Medical University, Sofia, 1431, Bulgaria

    Vihra Milanova

Authors
  1. Pamela Sklar
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  2. Sibylle G. Schwab
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  3. Nigel M. Williams
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  4. Mark Daly
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  5. Stephen Schaffner
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  6. Wolfgang Maier
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  7. Margot Albus
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  8. Matyas Trixler
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  9. Peter Eichhammer
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  10. Bernard Lerer
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  11. Joachim Hallmayer
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  12. Nadine Norton
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  13. Hywel Williams
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  14. Stan Zammit
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  15. Alastair G. Cardno
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  16. Sue Jones
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  17. Geraldine McCarthy
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  18. Vihra Milanova
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  19. George Kirov
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  20. Michael C. O'Donovan
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  21. Eric S. Lander
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  22. Michael J. Owen
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  23. Dieter B. Wildenauer
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Corresponding author

Correspondence to Pamela Sklar.

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Sklar, P., Schwab, S., Williams, N. et al. Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls. Nat Genet 28, 126–128 (2001). https://doi.org/10.1038/88836

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  • DOI: https://doi.org/10.1038/88836

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