Abstract
We have carried out a genome screen for atopic dermatitis (AD) and have identified linkage to AD on chromosomes 1q21, 17q25 and 20p. These regions correspond closely with known psoriasis loci, as does a previously identified AD locus on chromosome 3q21. The results indicate that AD is influenced by genes with general effects on dermal inflammation and immunity.
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References
Larsen, F.S., Holm, N.V. & Henningsen, K. J. Am. Acad. Dermatol. 15, 487–494 (1986).
Schultz Larsen, F. J. Am. Acad. Dermatol. 28, 719–723 (1993).
Juhlin, L., Johansson, G., Bennich, H., Hogman, C. & Thyresson, N. Arch. Dermatol. 100, 12–16 (1969).
Bos, J. Immunology of Atopic Dermatitis 178–185 (Blackwell Science, Oxford, 2000).
Lee, Y.A. et al. Nature Genet. 26, 470–473 (2000).
Becker, K. et al. Proc. Natl. Acad. Sci. USA 95, 9979–9984 (1998).
Cookson, W. Nature 402, B5–11 (1999).
Capon, F. et al. J. Invest. Dermatol. 112, 32–35 (1999).
Tomfohrde, J. et al. Science 264, 1141–1145 (1994).
Trembath, R. et al. Hum. Mol. Genet. 6, 813–820 (1997).
Enlund, F. et al. Eur. J. Hum. Genet. 7, 783–790 (1999).
Matthews, D. et al. Nature Genet. 14, 231–233 (1996).
Nair, R. et al. Hum. Mol. Genet. 6, 1349–1356 (1997).
Enlund, F. et al. Hum. Hered. 49, 2–8 (1999).
Hardas, B. et al. J. Invest. Dermatol. 106, 753–758 (1996).
Acknowledgements
We thank J.A. Faux for IgE estimations and L.R. Cardon for helpful comments on the linkage analyses. This study was funded by the Wellcome Trust.
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Cookson, W., Ubhi, B., Lawrence, R. et al. Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci. Nat Genet 27, 372–373 (2001). https://doi.org/10.1038/86867
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DOI: https://doi.org/10.1038/86867
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