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Following nature's anti-amyloid strategy

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Figure 1: The major species involved in protein folding (top to bottom direction) and protein aggregation (disordered aggregation to the left, ordered aggregation to the right).
Figure 2: An energy diagram that shows the relative energies of the species in Figure 1, along with the activation energies required for their interconversion (one determinant of the velocity).

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Lansbury, P. Following nature's anti-amyloid strategy. Nat Biotechnol 19, 112–113 (2001). https://doi.org/10.1038/84355

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