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Neurotrophin–3 is required for proper cerebellar development

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Abstract

Neurotrophin–3 (NT–3) is a member of the neurotrophin family, which includes nerve growth factor (NGF), brain–derived neurotrophic factor (BDNF) and neurotrophin–4/5 (NT–4/5). These factors are crucial for development of the peripheral nervous system1, but not the central nervous system (CNS), except that NT–3 and BDNF have been implicated in the postnatal development of the cerebellum2,3. Here we created a conditional NT–3–deficient mutant, which showed abnormal cerebellar morphology.

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Figure 1: Targeting strategy and Cre mediated recombination.
Figure 2: Cre–mediated recombination and expression of NT–3 in the conditional mutant.
Figure 3: Conditional mutants have aberrant cerebellar foliation but normal layering, external germinal layer proliferation and Purkinje arborization.

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Acknowledgements

The authors thank Peggy Lee and Steven O'Gormann for providing reagents. B.B. also thanks Jeanne Reis and Noah Duffey for technical support and Scharam Akbarian, Larry Schwartz and Kuo Fen Lee for comments on the manuscript. This research was supported by a grant from NIH/NCI.

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Author notes

  1. Maribel Rios and Andreas Trumpp: These authors contributed equally to this work

Authors and Affiliations

  1. Whitehead Institute for Biomedical Research,, 9 Cambridge Center, Cambridge, 02142, Massachusetts, USA

    Brian Bates, Maribel Rios, Cindy Chen, Guoping Fan & Rudolf Jaenisch

  2. G.W. Hooper Foundation, University of California, San Francisco, 94143, California, USA

    Andreas Trumpp & J. Michael Bishop

Authors
  1. Brian Bates
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  2. Maribel Rios
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  3. Andreas Trumpp
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  4. Cindy Chen
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  5. Guoping Fan
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  6. J. Michael Bishop
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  7. Rudolf Jaenisch
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Bates, B., Rios, M., Trumpp, A. et al. Neurotrophin–3 is required for proper cerebellar development. Nat Neurosci 2, 115–117 (1999). https://doi.org/10.1038/5669

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