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Signal transduction

How cells sense energy

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Maintaining an optimal cellular energy status requires sensing the levels of the adenine nucleotides ATP, ADP and AMP. Biochemical and structural studies of the enzyme AMPK provide insights into how this is achieved. See Letter p.230

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Figure 1: The new AMPK structure from two angles2.

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  1. D. Grahame Hardie is in the College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK.,

    D. Grahame Hardie

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  1. D. Grahame Hardie
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Correspondence to D. Grahame Hardie.

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Hardie, D. How cells sense energy. Nature 472, 176–177 (2011). https://doi.org/10.1038/472176a

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