Skip to main content

Advertisement

Log in

Immunology

A helpers' guide to infection

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

Killer T cells were thought to patrol the body unhindered, freely gaining access to sites of infection. But it seems that, at least in some body tissues, helper T cells must pave the way for killer T-cell entry.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1: Model of assisted entry.

Notes

  1. *This article and the paper under discussion3 were published online on 8 November 2009.

References

  1. Marshall, D. R. et al. Proc. Natl Acad. Sci. USA 98, 6313–6318 (2001).

    Article  ADS  CAS  Google Scholar 

  2. Masopust, D. et al. J. Immunol. 172, 4875–4882 (2004).

    Article  CAS  Google Scholar 

  3. Nakanishi, Y., Lu, B., Gerard, C. & Iwasaki, A. Nature 462, 510–513 (2009).

    Article  ADS  CAS  Google Scholar 

  4. Jennings, S. R., Bonneau, R. H., Smith, P. M., Wolcott, R. M. & Chervenak, R. Cell. Immunol. 133, 234–252 (1991).

    Article  CAS  Google Scholar 

  5. Lund, J. M., Hsing, L., Pham, T. T. & Rudensky, A. Y. Science 320, 1220–1224 (2008).

    Article  ADS  CAS  Google Scholar 

  6. Zhao, X. et al. J. Exp. Med. 197, 153–162 (2003).

    Article  CAS  Google Scholar 

  7. Wakim, L. M., Waithman, J., van Rooijen, N., Heath, W. R. & Carbone, F. R. Science 319, 198–202 (2008).

    Article  ADS  CAS  Google Scholar 

  8. McLachlan, J. B., Catron, D. M., Moon, J. J. & Jenkins, M. K. Immunity 30, 277–288 (2009).

    Article  CAS  Google Scholar 

  9. Cunningham, A. L. et al. J. Clin. Invest. 75, 226–233 (1985).

    Article  CAS  Google Scholar 

  10. Marzo, A. L. et al. J. Immunol. 165, 6047–6055 (2000).

    Article  CAS  Google Scholar 

  11. Butcher, E. C. & Picker, L. J. Science 272, 60–66 (1996)

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Gebhardt, T., Carbone, F. A helpers' guide to infection. Nature 462, 418–419 (2009). https://doi.org/10.1038/462418a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/462418a

  • Springer Nature Limited

Navigation