Genome-wide maps of methylated cytosine bases at single-base-pair resolution in human cells reveal distinct differences between cell types. These maps provide a starting point to decode the function of this enigmatic mark.
This is a preview of subscription content, log in via an institution to check access.
References
Lister, R. et al. Nature 462, 315–322 (2009).
Meissner, A. et al. Nature 454, 766–770 (2008).
Eckhardt, F. et al. Nature Genet. 38, 1378–1385 (2006).
Frommer, M. et al. Proc. Natl Acad. Sci. USA 89, 1827–1831 (1992).
Ramsahoye, B. H. et al. Proc. Natl Acad. Sci. USA 97, 5237–5242 (2000).
Zhang, X. et al. Cell 126, 1189–1201 (2006).
Zilberman, D. et al. Nature Genet. 39, 61–69 (2007).
Mohn, F. & Schübeler, D. Trends Genet. 25, 129–136 (2009).
Jones, P. A. et al. Nature 454, 711–715 (2008).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schübeler, D. Methylation matters. Nature 462, 296–297 (2009). https://doi.org/10.1038/462296a
Published:
Issue Date:
DOI: https://doi.org/10.1038/462296a
- Springer Nature Limited
This article is cited by
-
methylCC: technology-independent estimation of cell type composition using differentially methylated regions
Genome Biology (2019)
-
Adolescent idiopathic scoliosis (AIS), environment, exposome and epigenetics: a molecular perspective of postnatal normal spinal growth and the etiopathogenesis of AIS with consideration of a network approach and possible implications for medical therapy
Scoliosis (2011)