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Biological chemistry

Enzymes in focus

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The technique of directed evolution creates thousands of mutant enzymes from a single original. A new approach helps to search for variants that have an increased range of substrates — and can thus be used for organic synthesis.

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Figure 1: View of the enzyme active site used by Reetz et al.1 for pair mutation.

References

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Kazlauskas, R. Enzymes in focus. Nature 436, 1096–1097 (2005). https://doi.org/10.1038/4361096a

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