Skip to main content
SpringerLink
Log in

Inhibitory synapses

Anaesthetics set their sites on ion channels

  • News & Views
  • Published:

From Nature

View current issue Submit your manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1: Mihic et al.5 have found that single amino-acid substitutions at two positions remove the potentiating effects of volatile anaesthetics and ethanol on GABAA (γ-aminobutyric acid) and glycine receptors.

References

  1. Miller, K. W. & Pang, K.-Y. Y. Nature 263, 253–255 (1976).

    Article  ADS  CAS  Google Scholar 

  2. Lyon, R. C., McComb, J. A., Schreurs, J. & Goldstein, D. B. J. Pharmacol. Exp. Ther. 218, 669–675 (1981).

    Google Scholar 

  3. Franks, N. P. & Lieb, W. R. Nature 310, 599–601 (1984).

    Article  ADS  CAS  Google Scholar 

  4. Franks, N. P. & Lieb, W. R. Science 254, 427–430 (1991).

    Google Scholar 

  5. Mihic, S. J. et al. Nature 389, 385–389 (1997).

    Google Scholar 

  6. Unwin, N. Neuron 10, (Suppl.) 31-41 (1993).

  7. Harris, R. A., Mihic, S. J., Dildy-Mayfield, J. E. & Machu, T. K. FASEB J. 9, 1454–1462 (1995).

    Google Scholar 

  8. Franks, N. P. & Lieb, W. R. Nature 367, 607–614 (1994).

    Article  ADS  CAS  Google Scholar 

  9. Forman, S. A., Miller, K. W. & Yellen, G. Mol. Pharmacol. 48, 574–581 (1995).

    Google Scholar 

  10. Zhang, L., Oz, M., Stewart, R. R., Peoples, R. W. & Weight, F. F. Br. J. Pharmacol. 120, 353–355 (1997).

    Google Scholar 

  11. Belelli, D., Lambert, J. J., Peters, J. A., Wafford, K. & Whiting, P. J. Proc. Natl Acad. Sci. USA (in the press).

Download references

Author information

Authors and Affiliations

  1. the Biophysics Section, The Blackett Laboratory, Imperial College of Science, Technology and Medicine, SW7 2BZ, London, UK

    N. P. Franks & W. R. Lieb

Authors
  1. N. P. Franks
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. R. Lieb
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Franks, N., Lieb, W. Anaesthetics set their sites on ion channels. Nature 389, 334–335 (1997). https://doi.org/10.1038/38614

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/38614

  • Springer Nature Limited

This article is cited by

Search

Navigation