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CD22 regulates thymus-independent responses and the lifespan of B cells

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Abstract

THE B-lymphocyte-restricted glycoprotein CD22 is expressed on mature IgM+IgD+ B cells1–3, and is capable of binding to ligands on T and B cells2,4–7. CD22 can interact with both the B-cell antigen receptor (BCR) complex8,9 and signalling molecules, including the protein tyrosine phosphatase SHP1 (PTP1C, SHP)10–12, a putative negative regulator of BCR signalling13,14. Thus CD22 may facilitate interactions with lymphocytes and regulate the threshold of BCR signalling1,11,13. To define the in vivo function of CD22, we generated CD22-deficient mice. Here we show that CD22 is required for normal antibody responses to thymus-independent antigens and regulates the lifespan of mature B cells.

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Author notes

  1. Kristin B. Andersson

    Present address: Department of Biochemistry, University of Oslo, PB1041, Blindem, N-0316, Oslo, Norway

Authors and Affiliations

  1. Departments of Immunology, University of Washington Medical Center, Box 357660, Seattle, Washington, 98195, USA

    Kevin L. Otipoby, Stephen J. Klaus, Andrew G. Farr, James D. Kerner, Roger M. Perlmutter & Edward A. Clark

  2. Department of Microbiology, University of Washington Medical Center, Box 357660, Seattle, Washington, 98195, USA

    Kristin B. Andersson, Kevin E. Draves, Che-Leung Law & Edward A. Clark

  3. Department of Biological Structure, University of Washington Medical Center, Box 357660, Seattle, Washington, 98195, USA

    Andrew G. Farr

  4. Department of Biochemistry and Medicine, and the Howard Hughes Medical Institute, University of Washington Medical Center, Box 357660, Seattle, Washington, 98195, USA

    Roger M. Perlmutter

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  1. Kevin L. Otipoby
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  2. Kristin B. Andersson
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  3. Kevin E. Draves
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  4. Stephen J. Klaus
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  8. Che-Leung Law
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Otipoby, K., Andersson, K., Draves, K. et al. CD22 regulates thymus-independent responses and the lifespan of B cells. Nature 384, 634–637 (1996). https://doi.org/10.1038/384634a0

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  • DOI: https://doi.org/10.1038/384634a0

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