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Identification of a major co-receptor for primary isolates of HIV-1

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Abstract

Entry of HIV-1 into target cells requires cell-surface CD4 and additional host cell cofactors. A cofactor required for infection with virus adapted for growth in transformed T-cell lines was recently identified and named fusin. However, fusin does not promote entry of macrophage-tropic viruses, which are believed to be the key pathogenic strains in vivo. The principal cofactor for entry mediated by the envelope glycoproteins of primary macrophage-tropic strains of HIV-1 is CC-CKR-5, a receptor for the β-chemokines RANTES, MIP-1α and MIP-1β.

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Authors and Affiliations

  1. Skirball Institute for BioMolecular Medicine, New York University Medical Center, New York, New York, 10016, USA

    HongKui Deng, Wilfried Ellmeier, Derya Unutmaz, Michael Burkhart, Shoshana Marmon, C. Mark Hill, Craig B. Davis & Dan R. Littman

  2. Howard Hughes Medical Institute, New York University Medical Center, New York, New York, 10016, USA

    Derya Unutmaz & Dan R. Littman

  3. Aaron Diamond AIDS Research Center, Rockefeller University, New York, New York, 10016, USA

    Rong Liu, Sunny Choe, Paola Di. Marzio & Nathaniel R. Landau

  4. Department of Biochemistry, Stanford University Medical Center, Stanford, California, 94305, USA

    Richard E. Sutton

  5. James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, 40207, USA

    Stephen C. Peiper

  6. Department of Immunology, DNAX Research Institute, Palo Alto, California, 94304, USA

    Thomas J. Schall

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Deng, H., Liu, R., Ellmeier, W. et al. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381, 661–666 (1996). https://doi.org/10.1038/381661a0

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  • DOI: https://doi.org/10.1038/381661a0

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