Abstract
Germline mutation at human minisatellite loci has been studied among children born in heavily polluted areas of the Mogilev district of Belarus after the Chernobyl accident and in a control population. The frequency of mutation was found to be twice as high in the exposed families as in the control group. Mutation rate in the Mogilev families was correlated with the level of caesium-137 surface contamination, consistent with radiation induction of germline mutation.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Anspaugh, L. R., Catlin, R. J. & Goldman, M. Science 242, 1513–1519 (1988).
Kenigsberg, Y. I. & Minenko, V. F. in The Chernobyl Disaster: Medical Aspects (eds Stezko, V. A. et al.) 18–30 (Ministry of Health of Belarus, Minsk, 1994).
Kazakov, V. S., Demidchik, E. P. & Astakhova, L. N. Nature 359, 21 (1992).
Likhtarev, I. A. et al. Nature 375, 365 (1995).
Bochkov, N. P. Vest. ross. Akad. Med. Nank. 6, 51–56 (1993).
Lazjuk, G. I., Kirillova, I. A., Nikolaev, D. L. & Novikova, I. V. in The Chernobyl Papers Vol. 1. Doses to the Soviet Population and Early Health Effects Studies (eds Mervin, S. E. & Balanov, M.I.) 385–397 (Research Enterprises, Richland, WA, 1993).
Lazjuk, G. I., Kirillova, I. A., Dubrova, Y. E. & Novikova, I. V. Genetika 30, 1268–1273 (1994).
Jeffreys, A. J., Wilson, V. & Thein, S. L. Nature 316, 67–73 (1985).
Jeffreys, A. J., Royle, N. J., Wilson, V. & Wong, Z. Nature 332, 278–281 (1988).
Jeffreys, A. J., Turner, M. & Debenham, P. Am J. hum. Genet. 48, 824–840 (1991).
Dubrova, Y. E., Jeffreys, A. J. & Malashenko, A. M. Nature Genet. 5, 92–94 (1993).
Sadamoto, S. et al. Int. J. Radiat. Biol. 65, 549–557 (1994).
Fan, Y. F. et al. Int. j. Radiat. Biol. 68, 177–183 (1995).
Vergnaud, G. et al. Genomics 11, 135–144 (1991).
Monckton, D. G. et al. Nature Genet. 8, 162–170 (1994).
Orlov, M. Y. et al. Atom. Energy 72, 334–339 (1992).
Jeffreys, A. J., MacLeod, A., Tamaki, K., Neil, D. L. & Monckton, D. G. Nature 354, 204–209 (1991).
Jeffreys, A. J. et al. Nature Genet. 6, 136–145 (1994).
Ward, J. F. Int. J. Radiat. Biol. 57, 1141–1150 (1990).
Nelson, S. L., Giver, C. R. & Grosovsky, A. J. Carcinogenesis 15, 495–502 (1994).
Giver, C. R. et al. Carcinogenesis 16, 267–275 (1995).
Neel, J. V. et al. Am. J. hum. Genet. 42, 663–676 (1988).
Neel, J. V. et al. Am. J. hum. Genet. 46, 1053–1072 (1990).
Neel, J. V. in Well-Being of Mankind and Genetics. Proc. XIV Int. Congr. Genet. Vol. 1 (ed. Vartanian, M. E.) 235–238 (Mir, Moscow, 1980).
Luning, K. G. & Searle, A. G. Mutat. Res. 12, 291–304 (1971).
Kiefer, J., Muller, J. & Gotzen, J. Radiat. Res. 113, 71–78 (1988).
Crompton, N. E. A., Barth, B. & Kiefer, J. Radiat. Res. 124, 300–308 (1990).
Wong, Z. et al. Ann. hum. Genet. 51, 269–288 (1987).
Southern, E. M. Analyt. Biochem. 100, 319–323 (1979).
Drosdovitch, V. V., Minenko, V. F., Ulanovski, A. V. & Shemjakina, E. V. Prognosis of Doses of Exposure for Population of BSSR from the Caesium Radionuclides (Ministry of Health of Belarus, Minsk, 1989).
Kodaira, M., Satch, C., Hiyama, K. & Toyama, K. Am. j. hum. Genet 57, 1275–1283 (1995).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dubrova, Y., Nesterov, V., Krouchinsky, N. et al. Human minisatellite mutation rate after the Chernobyl accident. Nature 380, 683–686 (1996). https://doi.org/10.1038/380683a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/380683a0
- Springer Nature Limited
This article is cited by
-
Disproportionate Impacts of Radiation Exposure on Women, Children, and Pregnancy: Taking Back our Narrative
Journal of the History of Biology (2021)
-
A long-term investigation of environmental radioactivity and public health around a nuclear power plant
Journal of Radioanalytical and Nuclear Chemistry (2020)
-
Enhanced irreversible fixation of cesium by wetting and drying cycles in soil
Environmental Geochemistry and Health (2019)
-
Somatic health effects of Chernobyl: 30 years on
European Journal of Epidemiology (2017)
-
Follow-up studies on genome damage in children after Chernobyl nuclear power plant accident
Archives of Toxicology (2016)