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Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2

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Abstract

THE bmi-1 proto-oncogene can be activated by Moloney murine leukaemia proviral insertions in Eµ-myc transgenic mice1,2. It encodes a highly conserved nuclear protein of 324 amino acids which belongs to a family of proteins containing a putative new zinc-finger. Another closely related member of this family is the mouse protein Mel-18 (ref. 3). Here we report on the cloning and characterization of a homologous gene (D-bmi) from Drosophila melanogaster. Our analysis indicates that distinct domains of the mouse Bmi-1 protein, including the putative zinc-finger motif, are highly conserved within the much larger D-Bmi protein. Chromosomal localization and sequence comparison reveal that D-bmi is identical to Posterior Sex Combs (Psc)4-6 and indicate that the conserved domains between mouse bmi and Psc are also conserved within Suppressor-2 of Zeste (Su(z)2)6-8

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Author notes

  1. Manfred Frasch

    Present address: Mount Sinai Medical Center, 1 Gustave L. Levy Place, New York, New York, 10029, USA

Authors and Affiliations

  1. Division of Molecular Genetics, The Netherlands Cancer Institute and Department of Biochemistry, the University of Amsterdam, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    Maarten van Lohuizen, Ellen Wientjens & Anton Berns

  2. Max-Planck Institut für Entwicklungsbiologie, Abteilung Genetik, D-7400, Tübingen, Germany

    Manfred Frasch

Authors
  1. Maarten van Lohuizen
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  2. Manfred Frasch
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  3. Ellen Wientjens
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  4. Anton Berns
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van Lohuizen, M., Frasch, M., Wientjens, E. et al. Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2. Nature 353, 353–355 (1991). https://doi.org/10.1038/353353a0

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  • DOI: https://doi.org/10.1038/353353a0

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